Delivery of Lutein by Using Modified Burdock Polysaccharide Aggregates: Preparation, Characterization, and In Vitro Release Properties
文献类型： 外文期刊
作者： Zhang, Chenchen 1 ; Zhang, Yan 3 ; Song, Jiangfeng 1 ; Wang, Hongjuan 4 ; Wu, Caie 3 ; Li, Ying 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China
2.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China
3.Nanjing Forestry Univ, Coll Light Ind & Food Engn, Nanjing 210037, Peoples R China
4.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210014, Peoples R China
关键词： lutein; burdock polysaccharide; stearic acid; aggregates; release properties
期刊名称：POLYMERS （ 影响因子：4.7； 五年影响因子：4.9 ）
ISSN：
年卷期： 2024 年 16 卷 14 期
页码：
收录情况： SCI
摘要： Novel self-assembled aggregates of stearic acid (SA)-modified burdock polysaccharide (BP) for loading lutein were constructed, and the release and absorption properties of lutein in the aggregates in simulated gastrointestinal fluid were investigated. Three different degrees of substitution (DS) of SA-BPs were used to embed lutein, resulting in the encapsulation efficiency exceeding 90%. The aggregates were uniformly spherical, with a particle size range of 227-341 nm. XRD analysis revealed that lutein was present in a non-crystalline state within the aggregates. FT-IR and FS analysis demonstrated that lutein was located in the hydrophobic domains of SA-BP. The highest bioavailability of lutein in these aggregates reached 4.36 times that in the unmodified samples. These aggregates were able to remain stable in gastric juice and enhance the release rate of lutein in intestinal fluid. The transport of lutein-loaded SA-BP aggregates in Caco-2 cells competed with P-glycoprotein inhibitors, mainly promoting the transmembrane absorption of lutein through caveolae (or lipid raft)-related and clathrin-dependent endocytosis pathways. The above results suggest that SA-BP aggregates have the potential to be promising carriers for the efficient delivery of hydrophobic lutein.
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