Lipopolysaccharide accelerates tryptophan degradation in the ovary and the derivative kynurenine disturbs hormone biosynthesis and reproductive performance
文献类型： 外文期刊
作者： Shen, Jie 1 ; Zhao, Weimin 2 ; Cheng, Juanru 1 ; Cheng, Jinhua 2 ; Zhao, Lei 1 ; Dai, Chaohui 2 ; Fu, Yanfeng 2 ; Li, Bixia 2 ; Chen, Zhe 2 ; Shi, Deshun 1 ; Li, Hui 2 ; Deng, Yanfei 1 ;
作者机构： 1.Guangxi Univ, Coll Anim Sci & Technol, State Key Lab Conservat & Utilizat Subtrop Agrobio, Guangxi Key Lab Anim Breeding & Dis Control, Nanning 530004, Peoples R China
2.Jiangsu Acad Agr Sci, Inst Anim Sci, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base,Minist Sci & Technol, Nanjing 210014, Peoples R China
关键词： LPS; Tryptophan; Kynurenine; Granulosa cell; Reproduction
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：13.6； 五年影响因子：12.7 ）
ISSN： 0304-3894
年卷期： 2023 年 458 卷
页码：
收录情况： SCI
摘要： Lipopolysaccharide (LPS), also known as endotoxin, is a component of the outer membrane of gram-negative bacteria. LPS is released into the surrounding environment during bacterial death and lysis. Due to its chemi-cal and thermal stability, LPS can be detected anywhere and easily exposed to humans and animals. Previous studies have shown that LPS causes hormonal imbalances, ovarian failure, and infertility in mammals. However, the potential mechanisms remain unclear. In this study, we investigated the effects and mechanisms of LPS on tryptophan degradation, both in vivo and in vitro. The effects of kynurenine, a tryptophan derivative, on granulosa cell function and reproductive performance were explored. Results showed that p38, NF-& kappa;B, and JNK signaling pathways were involved in LPS-induced Ido1 expressions and kynurenine accumulation. Furthermore, the kynurenine decreased estradiol production, but increased granulosa cell proliferation. In vivo, experiments showed that kynurenine decreased estradiol and FSH production and inhibited ovulation and corpus luteum formation. Additionally, pregnancy and offspring survival rates decreased considerably after kynurenine treat-ment. Our findings suggest that kynurenine accumulation disrupts hormone secretion, ovulation, corpus luteal formation, and reproductive performance in mammals.
- 相关文献
作者其他论文 更多>>
-
Kynurenine, a derivative of tryptophan, inhibits progesterone biosynthesis in porcine granulosa luteal cells through Aryl hydrocarbon receptor-mediated downregulation of GATA-binding protein 4, 6, and CCAAT/enhancer-binding protein beta†
作者：Liao, Shiying;Deng, Yanfei;Liao, Shiying;Cheng, Jinhua;Zhao, Weimin;Dai, Chaohui;Fu, Yanfeng;Li, Bixia;Li, Hui;Li, Hui
关键词：kynurenine; progesterone; granulosa luteal cell; STAR; AHR
-
Population structure and genetic diversity of Mi pigs based on SINE-RIPs
作者：Wang, Xiaoyan;Zhou, Chenyu;Zheng, Yao;Yu, Miao;He, Jia;Chen, Cai;Qiao, Suwei;Moawad, Ali Shoaib;Song, Chengyi;Wang, Xiaoyan;Moawad, Ali Shoaib;Tian, Guoxing;Li, Bixia
关键词：Mi pig; retrotransposon insertion polymorphisms; SINE; genetic diversity; population structure
-
Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum
作者：Qiao, Heng;Zhao, Jing;Xiao, Liubin;Xu, Dejin;Xu, Guangchun;Tan, Yongan;Jiang, Qinhong;Shen, Jie;Yan, Shuo;Jiang, Qinhong;Shen, Jie;Yan, Shuo;Hao, Dejun;Zhu-Salzman, Keyan;Gu, Aiguo
关键词：
Apolygus lucorum ; Delivery system; Nanocarrier; RNA interference; RNA pesticide -
Effects of Different Levels of Lycium barbarum Flavonoids on Growth Performance, Immunity, Intestinal Barrier and Antioxidant Capacity of Meat Ducks
作者：Tu, Minhang;Cai, Gentan;Ma, Longfei;Wang, Tian;Wang, Chao;Yan, Leyan;Shi, Zhendan;Chen, Zhe;Yan, Leyan;Shi, Zhendan;Chen, Zhe
关键词：
Lycium barbarum flavonoids; meat duck; growth performance; intestinal function; antioxidation -
The Erk1/2-EGR1 signaling pathway is involved in lipopolysaccharide-induced transforming growth factor-beta 1 expression in mouse macrophages
作者：Zhao, Weimin;Wang, Hong;Dai, Chaohui;Li, Bixia;Fu, Yanfeng;Cheng, Jinhua;Li, Hui;Wang, Hong;Li, Hui
关键词：LPS; TGF-beta 1; Erk1/2; EGR1; Macrophage
-
Reproductive characteristics and methods to improve reproductive performance in goose production: A systematic review
作者：Yan, Leyan;Liu, Jie;Chen, Rong;Lei, Mingming;Guo, Binbin;Chen, Zhe;Dai, Zichun;Zhu, Huanxi
关键词：Goose; Reproduction; Light; Seasonal breeding; Broody behavior
-
Chlorogenic acid alleviates deoxynivalenol-induced damage in porcine trophectoderm cells by regulating the PI3K/AKT signaling pathway†
作者：Dai, Chaohui;Cheng, Jinhua;Li, Hui;Zhao, Weimin;Li, Bixia;Fu, Yanfeng;Wang, Xuemin;Liao, Chao;Yan, Junshu;Dai, Chaohui;Cheng, Jinhua;Li, Hui;Zhao, Weimin;Li, Bixia;Fu, Yanfeng;Wang, Xuemin;Liao, Chao;Yan, Junshu;Chen, Yanyu
关键词：pig; placental trophoblast cells; deoxynivalenol; chlorogenic acid; cell damage
