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Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis

文献类型: 外文期刊

作者: Wang, Peng-Cheng 1 ; Ran, Xin-Hui 1 ; Chen, Rui 1 ; Li, Liang-Chun 4 ; Xiong, Shan-Shan; Liu, Yu-Qing 1 ; Luo, Huai 1 ;

作者机构: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

4.Chinese Acad Sci, Chengdu Inst Bi

关键词: Valeriana officinalis;Valerianacae;Mononorsesquiterpenoid;Volvalerenone A;AChE inhibitory activity

期刊名称:TETRAHEDRON LETTERS ( 影响因子:2.415; 五年影响因子:2.036 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Volvalerenone A (1), a new type of mononorsesquiterpenoid with an unprecedented 5/6/6 tricyclic ring system, was isolated from the roots of Valeriana officinalis, the official species of valerian used in Europe. The structure of volvalerenone A was elucidated based on its spectroscopic and single-crystal X-ray crystallography data. The absolute configuration was assigned by the computational method. A possible bio-synthetic pathway of volvalerenone A was also proposed. Preliminary biological studies showed that volvalerenone A had weak inhibitory activity on acetylcholine esterase (AChE), and no enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PCI 2 cells was observed at 50 uM.

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