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A new 5-acyl-2-methylpyrrole from the endophytic fungus S20 of Cephalotaxus hainanensis

文献类型： 外文期刊

作者： Dai, Wen-jun 1 ; Dai, Hao-fu 1 ; Wu, Jiao 1 ; Liu, Jian 1 ; Mei, Wen-li 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Key Lab Trop Crop Biotechnol, Minist Agr, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

关键词： 5-acyl-2-methylpyrrole;Antibacterial activity;Cephalotaxus hainanensis;Endophytic fungus

期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：0.986； 五年影响因子：1.068 ）

ISSN：

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收录情况： SCI

摘要： A new 5-acyl-2-methylpyrrole, isolated from the endophytic fungus S20 of Cephalotaxus hainanensis, was elucidated as 1-(5-methyl-1H-pyrrol-2-yl)-2- ((2S*,3R*)-3-((E)-prop-1-enyl)oxiran-2-yl)ethanone (1) on the basis of spectroscopic evidence, including 1D- and 2D-NMR (HMQC, ~1H- ~1H COSY, HMBC and ROESY) and MS analysis. Compound 1 showed inhibitory effects on Staphylococcus aureus and methicillin-resistant S. aureus by the filter paper disc agar diffusion method.

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