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Supplemental magnolol or honokiol attenuates adverse effects in broilers infected with Salmonella pullorum by modulating mucosal gene expression and the gut microbiota

文献类型： 外文期刊

作者： Chen, Fang 1 ; Zhang, Hao 1 ; Du, Encun 1 ; Fan, Qiwen 1 ; Zhao, Na 1 ; Jin, Feng 1 ; Zhang, Wei 1 ; Guo, Wanzheng 1 ; Huang 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Wuhan, Peoples R China

2.Hubei Key Lab Anim Embryo & Mol Breeding, Wuhan, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Prevent & Control Agents Anim Bacteriosis, Wuhan, Peoples R China

关键词： Broiler; Gut microbiota; Honokiol; Immune; Magnolol; Salmonella pullorum

期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：5.032； 五年影响因子：5.922 ）

ISSN： 1674-9782

年卷期： 2021 年 12 卷 1 期

页码：

收录情况： SCI

摘要： Background Salmonella pullorum is one of the most harmful pathogens to avian species. Magnolol and honokiol, natural compounds extracted from Magnolia officinalis, exerts anti-inflammatory, anti-oxidant and antibacterial activities. This study was conducted to evaluate the effects of dietary supplemental magnolol and honokiol in broilers infected with S. pullorum. A total of 360 one-day-old broilers were selected and randomly divided into four groups with six replicates: the negative control group (CTL), S. pullorum-infected group (SP), and the S. pullorum-infected group supplemented with 300 mg/kg honokiol (SPH) or magnolol (SPM). Results The results showed that challenging with S. pullorum impaired growth performance in broilers, as indicated by the observed decreases in body weight (P < 0.05) and average daily gains (P < 0.05), along with increased spleen (P < 0.01) and bursa of Fabricus weights (P < 0.05), serum globulin contents, and the decreased intestine villus height and villus/crypt ratios (P < 0.05). Notably, supplemental magnolol and honokiol attenuated these adverse changes, and the effects of magnolol were better than those of honokiol. Therefore, we performed RNA-Seq in ileum tissues and 16S rRNA gene sequencing of ileum bacteria. Our analysis revealed that magnolol increased the alpha-diversity (observed species, Chao1, ACE, and PD whole tree) and beta-diversity of the ileum bacteria (P < 0.05). In addition, magnolol supplementation increased the abundance of Lactobacillus (P < 0.01) and decreased unidentified Cyanobacteria (P < 0.05) both at d 14 and d 21. Further study confirmed that differentially expressed genes induced by magnolol and honokiol supplementation enriched in cytokine-cytokine receptor interactions, in the intestinal immune network for IgA production, and in the cell adhesion molecule pathways. Conclusions Supplemental magnolol and honokiol alleviated S. pullorum-induced impairments in growth performance, and the effect of magnolol was better than that of honokiol, which could be partially due to magnolol's ability to improve the intestinal microbial and mucosal barrier.

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