HSP27-HSP40-HSP70-HSP90 pathway participated in molecular mechanism of selenium alleviating lead-caused oxidative damage and proteotoxicity in chicken Bursa of Fabricius
文献类型： 外文期刊
作者： Yu, Meijin 1 ; Jiang, Chunyu 1 ; Liang, Jiatian 1 ; Zhang, Hui 1 ; Teng, Xiaohua 1 ; Kang, Lu 1 ;
作者机构： 1.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin, Peoples R China
2.Xinjiang Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Urumqi, Peoples R China
3.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R China
4.Xinjiang Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Urumqi 830091, Peoples R China
关键词： Selenium; lead; heat shock protein; oxidative damage; proteotoxicity
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.141； 五年影响因子：1.92 ）
ISSN： 1049-5398
年卷期：
页码：
收录情况： SCI
摘要： Lead (Pb), a toxic environmental pollutant, is hazardous to the health of humans and birds. Bursa of Fabricius (BF) is a unique organ of birds. Toxic substances can attack BF and induce proteotoxicity. Increased heat shock proteins (HSPs) can induce oxidative damage. Selenium (Se) can alleviate harmful substance-caused oxidative damage. This study aimed to investigate whether Pb can cause oxidative damage and proteotoxicity, as well as Se reverse Pb-caused chicken BF toxicity. A model of chickens treated with Se and Pb alone and in combination was established. BFs were collected on days 30, 60, and 90. H&E and qRT-PCR were performed to observe the microstructure and to detect HSP27, HSP40, HSP60, HSP70, and HSP90 mRNA levels, respectively, in BFs. Multivariate correlation analysis and principal component analysis were conducted to explore the correlation among the five HSPs. In our results, Pb caused BF damage and up-regulated the five HSPs at three time points, causing oxidative damage and proteotoxicity via HSP27-HSP40-HSP70-HSP90 pathway. Furthermore, Pb caused time-dependent stress on HSP27, HSP40, HSP60, and HSP70. In addition, Se relieved Pb-caused damage and up-regulation of HSPs. Taken together, we concluded that Se alleviated Pb-caused oxidative injury and proteotoxicity in chicken BFs via the HSP27-HSP40-HSP70-HSP90 pathway.
- 相关文献
作者其他论文 更多>>
-
Nano-Selenium and Glutathione Enhance Cucumber Resistance to Botrytis cinerea by Promoting Jasmonic Acid-Mediated Cucurbitacin Biosynthesis
作者：Jia, Yujiao;Chen, Lanqi;Fu, Xiaorui;Zheng, Shuyang;Wu, Tong;Cai, Runze;Wan, Xiaoying;Wang, Ping;Pan, Canping;Jia, Yujiao;Chen, Lanqi;Fu, Xiaorui;Zheng, Shuyang;Wu, Tong;Cai, Runze;Wan, Xiaoying;Pan, Canping;Kang, Lu;Wu, Yangliu;Yin, Xuebin
关键词：Nano-Se; GSH; induced resistance; jasmonic acid; cucurbitacin; Botrytis cinerea
-
Isolation and Functional Characterization of a Constitutive Promoter in Upland Cotton (Gossypium hirsutum L.)
作者：Yang, Yang;Li, Xiaorong;Li, Chenyu;Zhang, Hui;Tuerxun, Zumuremu;Li, Juan;Liu, Zhigang;Chen, Guo;Cai, Darun;Chen, Xunji;Li, Bo;Li, Chenyu;Hui, Fengjiao
关键词：Gossypium hirsutum L.; GUS; constitutive promoter
-
Selenium Nanoparticle and Melatonin Treatments Improve Melon Seedling Growth by Regulating Carbohydrate and Polyamine
作者：Kang, Lu;Jia, Yujiao;Pan, Canping;Kang, Lu;Mao, Jiefei;Kang, Lu;Liu, Hejiang;Zhao, Duoyong;Ju, Yanjun;Wu, Yangliu
关键词：bio-stimulants; melon; primary metabolism; secondary metabolism
-
Chlorpyrifos induced autophagy and mitophagy in common carp livers through AMPK pathway activated by energy metabolism disorder
作者：Cui, Jiawen;Hao, Zhiyu;Zhou, Qin;Qiu, Minna;Liu, Yuhang;Liu, Yuhao;Teng, Xiaohua;Kang, Lu
关键词：Chlorpyrifos; Mitophagy; Autophagy; Oxidative stress; Glucose metabolism; IBR
-
Cadmium exposure caused cardiotoxicity in common carps (Cyprinus carpio L.): miR-9-5p, oxidative stress, energetic impairment, mitochondrial division/fusion imbalance, inflammation, and autophagy
作者：Liu, Yuhao;Lin, Xu;Hao, Zhiyu;Yu, Meijin;Teng, Xiaohua;Sun, Wei;Tang, You;Kang, Lu
关键词：Heavy metal; microRNA-9-5p; Energetic impairment; Mitochondrial dynamics; NF-& kappa;B-COX-2 axis; Autophagic injury
-
Cadmium induced time-dependent kidney injury in common carp via mitochondrial pathway: Impaired mitochondrial energy metabolism and mitochondrion-dependent apoptosis
作者：Cui, Jiawen;Liu, Yuhao;Hao, Zhiyu;Liu, Yuhang;Qiu, Minna;Teng, Xiaohua;Kang, Lu;Tang, You
关键词：Cadmium; Kidney injury; Mitochondrion; Energy metabolism; Apoptosis; Integrated biomarker response
-
Association analysis of agronomic traits and construction of genetic networks by resequencing of 306 sugar beet (Beta vulgaris L.) lines
作者：Wang, Liang;Hasi, Agula;Wang, Liang;Zhang, Ziqiang;Han, Pingan;Liang, Yahui;Zhang, Huizhong;Fu, Zengjuan;Zhao, Shangmin;Yuanyuan, E.;Zhang, Hui;Wu, Xinrong;Zhang, Bizhou;Chang, Yue;Tang, Kuangang;Zheng, Wenzhe;Li, Xiaodong;Bai, Chen;Chen, Li;Wang, Ronghua;Gao, Weishi
关键词：
