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Serious Risk of Tigecycline Resistance in Escherichia coli Isolated from Swine Manure

文献类型： 外文期刊

作者： Chen, Tao 1 ; Zhao, Minxing 1 ; Tang, Xiaoyue 1 ; Wang, Wenqiang 1 ; Zhang, Miao 1 ; Tang, Jing 1 ; Wang, Wei 1 ; Wei, Wenxiao 1 ; Ma, Baohua 7 ; Zou, Yongde 7 ; Zhang, Na 7 ; Mi, Jiandui 1 ; Wang, Yan 1 ; Liao, Xindi 1 ; Wu, Yinbao 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Peoples R China

2.Guangdong Lab Lingnan Modern Agr, Maoming Branch, Guangzhou 525000, Guangdong, Peoples R China

3.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, Guangzhou, Peoples R China

4.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China

5.Guangdong Engn Technol Res Ctr Harmless Treatment, Yunfu, Xinxing, Peoples R China

6.South China Agr Univ, Key Lab Trop Agr Environm, Minist Agr, Guangzhou 510642, Peoples R China

7.Foshan Customs Comprehens Technol Ctr, Foshan 528200, Peoples R China

关键词： Tetracycline resistance gene; Tigecycline; TetX family; Swine manure; E. coli; Doxycycline

期刊名称：MICROBIAL ECOLOGY （ 影响因子：4.192； 五年影响因子：4.608 ）

ISSN： 0095-3628

年卷期：

页码：

收录情况： SCI

摘要： The emergence of the plasmid-mediated tigecycline resistance gene tetX family in pig farms has attracted worldwide attention. The use of tetracycline antibiotics in pig farms has a facilitating effect on the prevalence of the tetX family, but the relationship among its presence, expression, and resistance phenotype in resistant bacteria is unknown. In this study, the presence and expression characteristics of tetracycline resistance genes (TRGs) in 89 strains of doxycycline-resistant E. coli (DRE) isolated from pig manure samples from 20 pig farms under low concentrations of doxycycline stress (2 mu g/mL) were analyzed. The detection rate of tetO was 96.63%, which is higher than those of other TRGs, such as tetA (94.38%), tetX (76.40%), tetB (73.03%), and tet(X4) (69.66%). At least three TRG types were present in DRE strains, which thus showed extensive resistance to tetracycline antibiotics, and 37% of these strains were resistant to tigecycline. In the presence of a low concentration of doxycycline, tetA played an important role, and the expression and existence ratio of TRGs indicated low expression of TRGs. Furthermore, the doxycycline resistance of DRE was jointly determined by the total absolute abundance of TRGs, and the absolute abundance of tetX and tet(X4) was significantly positively associated with tigecycline resistance in DRE (P < 0.05). Overall, DRE isolated from swine manure is an important reservoir of the tetX family, which suggests that DRE in swine manure has a high risk of tigecycline resistance, poses a potential threat to human health, and should be of public concern.

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