文献类型： 外文期刊
作者： Zhang, Kunli 1 ; Lin, Sen 3 ; Li, Jianhao 1 ; Deng, Shoulong 4 ; Zhang, Jianfeng 2 ; Wang, Sutian 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, Guangdong Key Lab Anim Breeding & Nutr, State Key Lab Livestock & Poultry Breeding, Guangzhou, Peoples R China
2.Minist Agr & Rural Affairs, Guangdong Acad Agr Sci, Inst Anim Hlth,Key Lab Livestock Dis Prevent Guan, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Guangzhou, Peoples R China
3.Guangdong Acad Agr Sci, Sericultural & AgriFood Res Inst, Guangzhou, Peoples R China
4.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing, Peoples R China
5.Peking Union Med Coll, Comparat Med Ctr, Beijing, Peoples R China
6.Guangdong Lab Lingnan Modern Agr, Maoming Branch, Guangzhou, Guangdong, Peoples R China
关键词： porcine enteric coronaviruses; innate immunity response; immune evasion; PEDV; PDCoV; TGEV; SADS-CoV
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：6.064； 五年影响因子：6.843 ）
ISSN：
年卷期： 2022 年 13 卷
页码：
收录情况： SCI
摘要： Host's innate immunity is the front-line defense against viral infections, but some viruses have evolved multiple strategies for evasion of antiviral innate immunity. The porcine enteric coronaviruses (PECs) consist of porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis coronavirus (TGEV), and swine acute diarrhea syndrome-coronavirus (SADS-CoV), which cause lethal diarrhea in neonatal pigs and threaten the swine industry worldwide. PECs interact with host cells to inhibit and evade innate antiviral immune responses like other coronaviruses. Moreover, the immune escape of porcine enteric coronaviruses is the key pathogenic mechanism causing infection. Here, we review the most recent advances in the interactions between viral and host's factors, focusing on the mechanisms by which viral components antagonize interferon (IFN)-mediated innate antiviral immune responses, trying to shed light on new targets and strategies effective for controlling and eliminating porcine enteric coronaviruses.
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