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Four Chemotherapeutic Compounds That Limit Blood-Brain-Barrier Invasion by Toxoplasma gondii

文献类型： 外文期刊

作者： Yan, Zijing 1 ; Yuan, Hao 1 ; Wang, Junjie 1 ; Yang, Zipeng 1 ; Zhang, Pian 1 ; Mahmmod, Yasser S. 5 ; Wang, Xiaohu 7 ; Liu, Tanghui 1 ; Song, Yining 1 ; Ren, Zhaowen 1 ; Zhang, Xiu-Xiang 8 ; Yuan, Zi-Guo 1 ;

作者机构： 1.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China

2.South China Agr Univ, Guangdong Prov Key Lab Zoonosis Prevent & Control, Guangzhou 510642, Peoples R China

3.South China Agr Univ, Minist Agr & Rural Affairs, Key Lab Zoonosis, Guangzhou 510642, Peoples R China

4.Xinjiang Agricultual Univ, Coll Vet Med, Urumqi 830052, Peoples R China

5.Zagazig Univ, Fac Vet Med, Dept Anim Med, Infect Dis, Zagazig 44511, Egypt

6.Al Ain Mens Coll, Higher Coll Technol, Vet Sci Div, Al Ain 17155, U Arab Emirates

7.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou 510640, Peoples R China

8.South China Agr Univ, Coll Agr, Guangzhou 510642, Peoples R China

关键词： toxoplasmic encephalitis; Toxoplasma gondii; blood-brain barrier; SB290157; CVF; NSC23766; Anxa1

期刊名称：MOLECULES （ 影响因子：4.927； 五年影响因子：5.11 ）

ISSN：

年卷期： 2022 年 27 卷 17 期

页码：

收录情况： SCI

摘要： Background: Toxoplasma gondii, an intracellular protozoan parasite, exists in the host brain as cysts, which can result in Toxoplasmic Encephalitis (TE) and neurological diseases. However, few studies have been conducted on TE, particularly on how to prevent it. Previous proteomics studies have showed that the expression of C3 in rat brains was up-regulated after T. gondii infection. Methods: In this study, we used T. gondii to infect mice and bEnd 3 cells to confirm the relation between T. gondii and the expression of C3. BEnd3 cells membrane proteins which directly interacted with C3a were screened by pull down. Finally, animal behavior experiments were conducted to compare the differences in the inhibitory ability of TE by four chemotherapeutic compounds (SB290157, CVF, NSC23766, and Anxa1). Results: All chemotherapeutic compounds in this study can inhibit TE and cognitive behavior in the host. However, Anxa 1 is the most suitable material to inhibit mice TE. Conclusion: T. gondii infection promotes TE by promoting host C3 production. Anxa1 was selected as the most appropriate material to prevent TE among four chemotherapeutic compounds closely related to C3.

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