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OxyR-Like Improves Cell Hydrogen Peroxide Tolerance by Participating in Monocyte Chemotaxis and Oxidative Phosphorylation Regulation in Magnetospirillum Gryphiswaldense MSR-1

文献类型： 外文期刊

作者： Ma, Yong 1 ; Guo, Fangfang 2 ; Zhang, Yunpeng 3 ; Sun, Xiuyu 1 ; Wen, Tong 1 ; Jiang, Wei 4 ;

作者机构： 1.Baotou Teachers Coll, Dept Biol Sci & Technol, Baotou 014030, Peoples R China

2.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing Key Lab Prevent & Control Infect Dis Live, Beijing 100097, Peoples R China

3.COFCO Corp, Nutr & Hlth Res Inst, Agr Utilizat Res Ctr, Beijing 102209, Peoples R China

4.China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing 100193, Peoples R China

关键词： OxyR-Like; Magnetospirillum Gryphiswaldense; Expression Profile; Hydrogen Peroxide Tolerance; Transcriptional Regulator

期刊名称：JOURNAL OF BIOMEDICAL NANOTECHNOLOGY （ 影响因子：3.641； 五年影响因子：3.354 ）

ISSN： 1550-7033

年卷期： 2021 年 17 卷 12 期

页码：

收录情况： SCI

摘要： The formation of magnetosomes inside magnetotactic bacteria is a complex process strictly controlled by the intracellular metabolic regulatory system. A series of transcriptional regulators are involved in the biosynthesis of the magnetosome, including OxyR-Like protein, which is indispensable for the maturation of magnetosomes in Magnetospirillum gryphiswaldense MSR-1. In this study, a new function of the OxyR-Like protein that helps cells resist reactive oxygen species (ROS) was identified. A comparison of expression profile data between wild-type MSR-1 and an oxyR-Like defective mutant demonstrated that seven genes encoding chemotaxis proteins were down-regulated in the latter. On the contrary, the expression levels of numerous genes encoding proteins that are critical for cellular aerobic respiration were up-regulated. Thus, OxyR-Like enhanced the resistance of cells to ROS by increasing their environmental perception and maintaining their oxidative phosphorylation at a reasonable level to avoid the excessive production of endogenous ROS. These results increase our knowledge of the OxyR-Like regulatory network and establish a relationship between the antioxidant metabolic pathway and magnetosome biomineralization in MSR-1.

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