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Sialic acid profiles in the respiratory tracts of selected species of raptors: Evidence for potential binding sites for human and avian influenza A viruses

文献类型： 外文期刊

作者： Han, Chun-Hua 1 ; Lin, Jian 1 ; Wang, Xiuqing 2 ; Han, Jing-Wen 1 ; Duan, Hui-Juan 1 ; Pan, Jie 1 ; Liu, Yue-Huan 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim & Husb Med, Beijing 100097, Peoples R China

2.S Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA

关键词： influenza A virus;MAA;raptor;SAα2;3-Gal;SAα2;6-Gal;SNA

期刊名称：WILDLIFE RESEARCH （ 影响因子：2.511； 五年影响因子：2.79 ）

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收录情况： SCI

摘要： Context The ability of influenza A viruses to recognise and bind to cell surface receptors such as sialic acid linked to galactose by an 2,3 linkage (SA2,3-gal) and sialic acid linked to galactose by an 2,6 linkage (SA2,6-gal) is a major determinant of influenza A virus infection. Although the epidemiological surveys of influenza A virus infection in raptors suggest that some raptor species are susceptible to influenza A viruses under natural conditions, the sialic acid profiles in the respiratory and intestinal tracts of raptors are unknown. Aims To examine the sialic acid receptor profiles in the respiratory tracts of the selected raptor species and assess the potential susceptibility of raptors to avian and human influenza viruses and the role of raptors in the epidemiology and evolution of influenza A viruses. Methods The lectin immunohistochemistry staining method was used to examine the sialic acid profiles in the respiratory tracts of eight different species of raptors. Key results A strong staining with Maackia amurensis agglutinin (MAA), specific for sialic acid linked to galactose by an 2,3 linkage (SA2,3-gal), was observed in the epithelial cells of the respiratory tract of Accipiter nisus and Falco tinnunculus. However, a positive staining for both MAA and Sambucus nigra agglutinin (SNA), specific for sialic acid linked to galactose by an 2,6 linkage (SA2,6-gal), was detected in the epithelial cells of the upper respiratory tract of Accipiter gularis, Buteo buteo, Otus sunia, Bubo bubo and Asio otus, and in the epithelial cells of the alveoli of Buteo buteo, Falco peregrinus, Otus sunia and Bubo bubo. Conclusions Both avian and human influenza A virus receptors are expressed in six species of raptors examined. There are some variations in the type and distribution of sialic acid receptor expression among different raptor species. No correlation between phylogeny of birds and their sialic acid receptor distributions was observed. Implications Since SA2,3-gal and SA2,6-gal are often considered as the primary receptors for avian influenza A viruses and human influenza A viruses, respectively, our data suggest that raptors could be a potential host for avian and human influenza A viruses.

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