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Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells

文献类型： 外文期刊

作者： Miao, Jinfeng 1 ; Zhang, Jinqiu 2 ; Zheng, Liuhai 1 ; Yu, Xiaoming 1 ; Zhu, Wei 1 ; Zou, Sixiang 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Vaccine Engn & Technol China, Nanjing 210014, Jiangsu, Peoples R China

关键词： Taurine;Streptococcus uberis;Mastitis;Rat;Tregs

期刊名称：AMINO ACIDS （ 影响因子：3.52； 五年影响因子：3.6 ）

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收录情况： SCI

摘要： Taurine (Tau) is reported to have a key role in the regulation of the innate immune response and thus reduce tissue damage induced by bacterial infection. In this study, the effects of Tau on a rat model of mastitis induced by Streptococcus uberis (S. uberis) and the changes of T regulatory cells (Tregs) were assessed. Starting on gestation day 14 and continuing until parturition, 100 mg/kg of taurine (group TS) or an equal volume of physiological saline (group CS) was administered daily, per os. Seventy-two hours after parturition, rats were infused with approximately 100 cfu of S. uberis into each of two mammary glands. The results showed that the resultant inflammation, evidenced by swelling, secretory epithelial cell degeneration, increased adipose tissue and neutrophil (PMN) infiltration were evident in mammary tissue following injection with S. uberis. Pre-treatment with Tau attenuated these morphologic changes, the expression of interleukin (IL)-2, interferon (INF)-γ mRNA, myeloperoxidase (MPO) activity and N-acetyl-β-D-glucosaminidase (NAGase) in mammary tissue. The percentages of Foxp3 + CD25 + CD4 +/lymphocytes (Tregs) were dramatically increased after the S. uberis challenge. Significant differences (P < 0.05) were observed at 24, and 72 h post S. uberis - injection (PI) in CS. Pre-treatment further increased the percentage of Tregs and a significant difference between CS and TS (P < 0.05) was apparent at 24 h PI. Our data indicate that in rats, Tau can be used to regulate the immune response following infection by S. uberis and consequently prevent mammary tissue damage by increasing Tregs.

  • 相关文献

[1]The effect of taurine on the toll-like receptors/nuclear factor kappa B (TLRs/NF-kappa B) signaling pathway in Streptococcus uberis-induced mastitis in rats. Miao, Jinfeng,Zheng, Liuhai,Ma, Zili,Zhu, Wei,Zou, Sixiang,Zhang, Jinqiu. 2011

[2]The role of NADPH oxidase in taurine attenuation of Streptococcus uberis-induced mastitis in rats. Miao, Jinfeng,Ma, Zili,Zheng, Liuhai,Zhang, Jinqiu. 2013

[3]The role of Ca2+ mediated signaling pathways on the effect of taurine against Streptococcus uberis infection. Dai, Bin,Liu, Ming,Zhang, Yuanshu,Xu, Yuanyuan,Miao, Jinfeng,Zhang, Jinqiu,Lu, Jinye,Yin, Yulong.

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