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New serratene triterpenoids from Palhinhaea cernua and their cytotoxic activity

文献类型： 外文期刊

作者： Yan, Jian 1 ; Zhou, Zhong-Yu 1 ; Zhang, Mei 1 ; Wang, Jing 1 ; Dai, Hao-Fu 2 ; Tan, Jian-Wen 1 ;

作者机构： 1.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China

2.Chinese Acad Trop Agr Sci, State Key Lab Trop Crops Biotechnol, Inst Trop Biosci & Biotechnol, Haikou, Peoples R China

3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

关键词： cytotoxic activity;Lycopodiaceae;Palhinhaea cernua;serratene;triterpenoid

期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Four new serratene triterpenoids, 3β,21β,24-trihydroxyserrat-14- en-24-(4-hydroxybenzoate) (1), 3β,21α,24-trihydroxyserrat-14-en-3-(4- hydroxybenzoate) (2), 3β,14α,15α,21α-tetrahydroxyserrat- 14-en-3-(3-methoxyl-4-hydroxybenzoate) (3), and 3β,14α,15α, 21α-tetrahydroxyserrat-14-en-21-acetyl-3-(4-hydroxybenzoate) (4), together with two known ones, 5 and 6, were isolated from whole plants of Palhinhaea cernua. The structures of these new compounds were elucidated by spectroscopic methods. All the six compounds were tested for their in vitro cytotoxicity against three human cancer cell lines (K562, SMMC-7721, and SGC7901). Compound 5 showed cytotoxicity against the three test cell lines with ICvalues of 20.3, 34.0, and 22.5 ug/mL, respectively. Compound 1 showed slight cytotoxicity against K562 cell lines with ICvalue of 56.1 ug/mL, while no obvious inhibitory effects were detected for other compounds.

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