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Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation

文献类型: 外文期刊

作者: Shi, Liqiao 1 ; Hui, Rui 1 ; Wei, Yanhong 1 ; Liang, Ying 1 ; Yang, Ziwen 1 ; Ke, Shaoyong 1 ;

作者机构: 1.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China

关键词: Anthranilic diamides;Antitumor activity;Aryl-isoxazoline;Synthesis

期刊名称:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ( 影响因子:6.514; 五年影响因子:6.099 )

ISSN:

年卷期:

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收录情况: SCI

摘要: A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by 1H NMR, 13C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential anticancer agents.

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