您好,欢迎访问湖北省农业科学院 机构知识库!

Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation

文献类型: 外文期刊

作者: Shi, Liqiao 1 ; Hui, Rui 1 ; Wei, Yanhong 1 ; Liang, Ying 1 ; Yang, Ziwen 1 ; Ke, Shaoyong 1 ;

作者机构: 1.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China

关键词: Anthranilic diamides;Antitumor activity;Aryl-isoxazoline;Synthesis

期刊名称:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ( 影响因子:6.514; 五年影响因子:6.099 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by 1H NMR, 13C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential anticancer agents.

  • 相关文献

[1]Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents. Ke, Shaoyong,Shi, Liqiao,Yang, Ziwen.

[2]Synthesis of Novel Steroid Derivatives Derived from Dehydroepiandrosterone as Potential Anticancer Agents. Ke, Shaoyong,Shi, Liqiao,Yang, Qingyu,Yang, Ziwen,Wei, Yanhong,Yang, Ziwen. 2013

[3]Synthesis, antitumor activity and mechanism of action of novel 1,3-thiazole derivatives containing hydrazide-hydrazone and carboxamide moiety. He, Haifeng,Wang, Xiaoyan,He, Hongwu,Shi, Liqiao,Yin, Wenyan,Yang, Ziwen,Liang, Ying. 2016

[4]Synthesis and Biological Activity of a Series of Novel N-Substituted beta-Lactams Derived from Natural Gallic Acid. Ke, Shao-Yong,Cao, Xiu-Fang,Wang, Yun-Shen,Li, Shao-Wei,Chen, Chang-Shui. 2011

[5]Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation. Peng, Min,Shi, Liqiao,Ke, Shaoyong. 2017

[6]Structural diversity-guided convenient construction of functionalized 4H-1,3,4-oxadiazin-5(6H)-one derivatives. Ke, Shaoyong,Wang, Kaimei,Zhang, Zhigang,Zhang, Ya-Ni,Liang, Ying,Shi, Liqiao,Jiang, Aibing,Yang, Ziwen.

[7]Synthesis, Crystal Structure and Biological Activity of alpha-(5-Chloro-3-trifluoromethyl-1-phenylpyrazol-4-carbonyloxy)-alpha-arylmethyl Phosphonates. Liang Ying,He Haifeng,Yang Ziwen,Liang Ying,He Hongwu,He Haifeng. 2012

[8]Novel amide-type ligand bearing bis-pyridine cores: Synthesis, spectral characterizations and X-ray structure analyses. Ke, Shaoyong. 2016

[9]Synthesis and Biological Properties of Dihydro-Oxadiazine-Based Heterocyclic Derivatives. Ke, S.,Liang, Y.,Wang, K.,Yang, Z.,Cao, X.. 2011

[10]Oxime Carbamates as Potential Insecticidal Agents: Design, Synthesis and Biological Evaluation. Ke, Shaoyong,Yang, Ziwen,Shi, Liqiao,Liu, Manli,Liang, Ying,Wang, Kaimei,Long, Tong,Jiang, Aibing,Zhang, Zhigang. 2015

[11]Synthesis and Biological Activities of N '-Pyridyl(thiazolyl) Methyloxyphenyl-N-arylacyl Urea Derivatives. Liang Ying,Zhang Zhigang,Wei San,Yang Ziwen. 2011

[12]Progress in the Studies on Synthesis and Biological Properties of Butenolide and Its Derivatives. Cao Xiufang,Sun Tingting,Ke Shaoyong. 2010

[13]Synthesis, Crystal Structure and Biological Activity of 6-Alkyl-7-imino-3-phenyl-2-thioxo-2,3,6,7-tetrahydrothiazolo[4,5-d]pyrimidines. Liang Ying,He Hongwu,Liang Ying. 2009

[14]Substituted-nicotinyl thiourea derivatives bearing pyrimidine moiety: synthesis and biological evaluation. Ke, Shaoyong,Cao, Xiufang.

[15]Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: design, synthesis, characterization, and biological evaluation. Ke, Shaoyong,Zhang, Zhigang,Long, Tong,Liang, Ying,Yang, Ziwen.

[16]Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation. Ke, Shaoyong,Yang, Ziwen,Wang, Kaimei,Liang, Ying,Shi, Liqiao,Wei, Yanhong.

[17]Synthesis of Novel (E)-alpha-(methoxyimino) Benzeneacetate Derivatives and their Fungicidal Activities. Wang, Xianyou,Chen, Peiyun,Pang, Yanping,Zhao, Zhilei,Wu, Guangchen,Wang, Hua.

[18]Spirodiclofen Analogues as Potential Lipid Biosynthesis Inhibitors: A Convenient Synthesis, Biological Evaluation, and Structure-Activity Relationship. Ke, Shaoyong,Sun, Tingting,Zhang, Zhigang,Zhang, Ya-Ni,Liang, Ying,Wang, Kaimei,Yang, Ziwen.

[19]Novel ether-functional spiro-tetronic acid derivatives: molecule design, convenient synthesis and biological evaluation. Ke, Shaoyong,Zhang, Zhigang,Zhang, Ya-Ni,Shi, Liqiao,Zhou, Ronghua,Jiang, Aibing,Liang, Ying,Yang, Ziwen.

[20]Acylhydrazone derivatives as potential anticancer agents: Synthesis, bio-evaluation and mechanism of action. Yu, Xifang,Shi, Liqiao,Ke, Shaoyong.

作者其他论文 更多>>