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Heterocycle-functional gramine analogues: Solvent- and catalyst-free synthesis and their inhibition activities against cell proliferation

文献类型: 外文期刊

作者: Ke, Shaoyong 1 ; Shi, Liqiao 1 ; Cao, Xiufang 2 ; Yang, Qingyu 1 ; Liang, Ying 1 ; Yang, Ziwen 1 ;

作者机构: 1.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China

2.Huazhong Agr Univ, Coll Sci, Wuhan 430070, Peoples R China

关键词: Cell proliferation;Gramine analogues;Inhibition activity;Synthesis

期刊名称:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ( 影响因子:6.514; 五年影响因子:6.099 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: A series of novel gramine analogues were designed and synthesized via a convenient three-component reaction, and which were evaluated for their inhibition activities against cell proliferation. Their structures were confirmed by satisfactory spectra analyses mainly including 1H NMR, and ESI-MS analyses. The preliminary assays indicated that some of the newly synthesized compounds displayed significantly good inhibition activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) cell lines compared with the control 5-Fluorouracil (5-FU), which might be developed as novel lead scaffold for potential anticancer agents.

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