您好，欢迎访问湖北省农业科学院 机构知识库！
湖北省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Complete genome sequence and molecular characterization of thermostable newcastle disease virus strain Ts09-C

文献类型： 外文期刊

作者： Wen, Guoyuan 1 ; Shang, Yu 3 ; Guo, Jing 3 ; Chen, Chen 3 ; Shao, Huabin 1 ; Luo, Qingping 1 ; Yang, Jun 1 ; Wang, Hongli 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Wuhan 430072, Peoples R China

2.Hubei Key Lab Anim Embryo & Mol Breeding, Wuhan 430072, Peoples R China

3.Huazhong Agr Univ, Vet Pathol Lab, Acad Vet Med, Wuhan 430072, Peoples R China

关键词： Complete genome sequence;Newcastle disease virus;Strain TS09-C;Thermostable

期刊名称：VIRUS GENES （ 影响因子：2.332； 五年影响因子：2.0 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A thermostable avirulent Newcastle disease virus (NDV) strain TS09-C was developed by serial passage of V4 strain in BHK-21 cells. The complete genome sequence of strain TS09-C was determined and compared with the sequences of other NDV isolates representing different thermostable phenotypes. The TS09-C genome was 15,186 nucleotides long and consisted of eight genes in the order of 3′-NP-P/V/W-M-F-HN-L-5′. High levels of nucleotide and amino acid sequence identity existed among the thermostable NDV isolates. Thermostable strains TS09-C, V4, I-2, and Ulster all belonged to genotype I. The F protein cleavage site of strain TS09-C was 112G-K-Q-R-R-L117, with an isolated basic amino acid and a pair of contiguous basic amino acids, differing from that of its parental V4 strain (112G-K-Q-G-R-L 117). Our characterization of the complete genome of thermostable avirulent NDV strain TS09-C may facilitate the development of a thermostable NDV reverse genetic system and further study of the mechanism of thermostability of NDV.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：湖北省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台