文献类型： 外文期刊

作者： Wu, Jianguo ¹ ; Wu, Yanbin ¹ ; Peng, Wei ² ; Chen, Tiqiang ³ ; Wang, Minhui ⁴ ; Wu, Jinzhong ¹ ;

作者机构： 1.Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R China

2.Third Mil Med Univ, Coll Pharm, Dept Pharmacol, Chongqing 400038, Peoples R China

3.Fujian Acad Agr Sci, Inst Edible & Med Fungi, Fuzhou 350014, Peoples R China

4.Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R China

关键词： chemical composition;spore lipids;ganoderma

期刊名称：CHEMISTRY OF NATURAL COMPOUNDS （ 影响因子：0.809； 五年影响因子：0.708 ）

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收录情况： SCI

摘要： Ganoderma, commonly referred to as “Lingzhi” in Chinese, “Reizhi” in Japanese, and “Youngzhi” in Korean, is a family of medicinal mushrooms employed to maintain human vitality and to promote longevity in traditional Chinese medicine for over 2000 years [1]. To date, Ganoderma has been used as remedy for the treatment of various diseases such as migraine and headache, hypertension, arthritis, hepatitis, cardiovascular problems, and cancer. It has been shown to contain a variety of bioactive ingredients including trierpenes, polysaccharides, nucleosides, steroids, fatty acids, alkaloids, proteins, peptides, amino acids, and inorganic elements [2]. Recently, Ganoderma spores gained considerable attention owning to their possible higher bioactivity [3]. However, spores have extremely hard and resilient bilayer walls, thus making them difficult to break open, and their bioactive lipid is stored between the inner and outer walls and is difficult to extract [4]. The difficulty above could be overcome by using superfine grinding technology through breaking the sporoderm and removing plant cellulose barriers [5]. Furthermore, it was reported that alcohol extracts from sporoderm-broken spores were more cytotoxic against tumor cells than that from sporoderm-nonbroken spores [6]. Super CO_2 fluid extraction (SFE), a well-known extract technology, was established to extract liposoluble materials, which presented some advantages such as being nontoxic, high-efficiently, and less-deteriorating compared with the conventional methods viz. hydrodistillation, steam distillation, or solvent extraction [7].