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Chemical Constituents from Ligustrum lucidum Differentially Promote Bone Formation and Prevent Oxidative Damage in Osteoblastic UMR-106 cells

文献类型： 外文期刊

作者： Huang, Yunxi 1 ; Wu, Yanbin 1 ; Wu, Jianguo 1 ; Yi, Jun 2 ; Zhang, Qiaoyan 3 ; Chen, Tiqiang 4 ; Wu, Jinzhong 1 ;

作者机构： 1.Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350122, Peoples R China

2.Fujian Inst Educ, Dept Chem & Life Sci, Fuzhou 350025, Peoples R China

3.Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China

4.Fujian Acad Agr Sci, Fuzhou 350013, Peoples R China

关键词： Alkaline phosphatase;Anti-osteoporosis;Ligustrum lucidum;Osteoblast;Oxidative stress

期刊名称：LATIN AMERICAN JOURNAL OF PHARMACY （ 影响因子：0.249； 五年影响因子：0.25 ）

ISSN： 0326-2383

年卷期： 2014 年 33 卷 2 期

页码：

收录情况： SCI

摘要： Twelve compounds isolated from the fruits of Ligustrum lucidum (FLL), including four phenethanols, three secoiridoids and five flavonoids, viz. tyrosol (1), hydroxytyrosol (2), salidroside (3), acteoside (4), oleuropein (5), specnuzhenide (6), G13 (7), luteolin (8), luteolin-7-O-beta-D-glucopyranoside (9), apigenin (10), apigenin-7-O-beta-D-glucopyranoside (11), and apigenin-7-O-acetyl-beta-D-glucopyranoside (12) were evaluated for their activity on osteoblast viability and differentiation, and the preventive effect on oxidative damage of osteoblastic UMR-106 cells by hydrogen peroxide. Compounds 3, 4, 5, 6, 7, 9, 10, 11 and 12 significantly increased the viability as well as ALP (alkaline phosphatase) activity in UMR-106 cells. Compounds 1, 2, 10 and 11 could protect osteoblasts against H2O2-induced cell injury, and compounds 1, 2, 11, 12 could attenuate H2O2 decreased the level of ALP activity on UMR-106 cells significantly. These results indicated that these compounds, such as phenylethanoids, secoiridoids and flavonoids are principally responsible for the antiosteoporotic effect of FLL.

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