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The preparation of gypenosides liposomes and its effects on the peritoneal macrophages function in vitro

文献类型： 外文期刊

作者： Yu, Yun 1 ; Lu, Yu 2 ; Bo, Ruonan 1 ; Huang, Yee 1 ; Hu, Yuanliang 1 ; Liu, Jiaguo 1 ; Wu, Yi 1 ; Tao, Yang 1 ; Wang, Deyun 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Biol Engn & Technol, Nanjing 210014, Jiangsu, Peoples R China

关键词： Cytokine;Gypenosides liposome;Optimization;Peritoneal macrophages;Phagocytic activity;Response surface methodology

期刊名称：INTERNATIONAL JOURNAL OF PHARMACEUTICS （ 影响因子：5.875； 五年影响因子：5.423 ）

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收录情况： SCI

摘要： Optimization of preparation of gypenosides liposome (GPSL) was investigated with response surface methodology (RSM) and the effect of GPSL activating phagocytosis activity and cytokine secretion of macrophages was determined in the paper. The results showed that the optimal conditions of GPSL preparation were as follows: the ratio of lipid to drug (w/w) of 8:1, the ratio of soybean phospholipid to cholesterol (w/w) of 6:1, the temperature of incubation of drug in water bath of 55 C, the time of incubation of drug of 11 min. With the condition, the experimental encapsulation efficiency of GPSL was 90.17 ± 0.38%. In addition, GPSL could significantly enhance phagocytosis activity and the secretion of cytokines of the peritoneal macrophages of mice. These indicated that GPSL with high entrapping efficiency and small particle size could be prepared by ethanol injection combined with ammonium sulfate gradient method, which is applied easily, and GPSL could enhance the activity of peritoneal macrophages.

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