您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Protective efficacy of a live attenuated Mycoplasma hyopneumoniae vaccine with an ISCOM-matrix adjuvant in pigs

文献类型： 外文期刊

作者： Xiong, Qiyan 1 ; Wei, Yanna 1 ; Feng, Zhixin 1 ; Gan, Yuan 1 ; Liu, Zhanjun 1 ; Liu, Maojun 1 ; Bai, Fangfang 2 ; Shao, G 1 ;

作者机构： 1.Natl Ctr Engn Res Vet Bioprod, Minist Agr, Key Lab Vet Biol Engn & Technol, Inst Vet Med,Jiangsu Acad Agr Sci, Nanjing 210014, Jiangsu, Peoples R China

2.Natl Ctr Engn Res Vet Bioprod, Minist Agr, Key Lab Vet Biol Engn & Technol, Inst Vet Med,Jiangsu Acad Agr

关键词： Pig;Adjuvant;Intramuscular vaccine;Mycoplasma hyopneumoniae

期刊名称：VETERINARY JOURNAL （ 影响因子：2.688； 五年影响因子：2.857 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： An attenuated Mycoplasma hyopneumoniae vaccine that requires intrathoracic administration is commercially available for use against mycoplasmal pneumonia in China. Given the limitations of such a route of administration, this study was undertaken to assess the capacity of an ISCOM-matrix adjuvant to enhance immunogenicity following intramuscular use. Immune responses in pigs following vaccination and subsequent intra-tracheal bacterial inoculation were examined using lymphocyte proliferation, serology and mucosal IgA in both nasal and saliva swabs. Vaccination induced clear lymphocyte proliferation, but only slight serum antibody responses although these were significantly increased following experimental infection. Mucosal IgA was not detected in either nasal or salivary secretions. Following bacterial challenge, animals vaccinated with the adjuvant-containing live vaccine exhibited less severe pulmonary lesions (median score 3.67) than unvaccinated pigs (median score 13.58). The degree of ciliary loss on the respiratory tract surface was reduced in vaccinated pigs compared with experimentally infected controls. The findings indicated that the adjuvant vaccine administered IM provided protection against experimentally induced mycoplasmal pneumonia and could have commercial potential.

  • 相关文献

[1]Effect of different adjuvant formulations on the immunogenicity and protective effect of a live Mycoplasma hyopneumoniae vaccine after intramuscular inoculation. Wang, Chunlai,Xie, Fang,Xiong, Qiyan,Wei, Yanna,Xie, Haidong,Feng, Zhixin,Gan, Yuan,Liu, Maojun,Bai, Fangfang,Shao, Guoqing.

[2]CYP1A1 mediates the suppression of major inflammatory cytokines in pulmonary alveolar macrophage (PAM) cell lines caused by Mycoplasma hyponeumoniae. Fang, Xiaomin,Zhao, Weimin,Xu, Jie,Tu, Feng,Wang, Xuemin,Li, Bixia,Fu, Yanfeng,Ren, Shouwen.

[3]Use of serological and mucosal immune responses to Mycoplasma hyopneumoniae antigens P97R1, P46 and P36 in the diagnosis of infection. Feng, Zhi-Xin,Bai, Yun,Yao, Jing-Ting,Gan, Yuan,Wang, Hai-Yan,Wei, Yan-Na,Liu, Mao-Jun,Xiong, Qi-Yan,Bai, Fang-Fang,Li, Bin,Wu, Xu-Su,Shao, Guo-Qing,Feng, Zhi-Xin,Bai, Yun,Liu, Mao-Jun,Shao, Guo-Qing,Pharr, G. Todd,Wan, Xiu-Feng,Xiao, Shao-Bo,Chi, Ling-Zhi.

[4]Vaccination inhibits TLR2 transcription via suppression of GR nuclear translocation and binding to TLR2 promoter in porcine lung infected with Mycoplasma hyopneumoniae. Sun, Zhiyuan,Liu, Maojun,Zou, Huafeng,Li, Xian,Zhao, Ruqian,Liu, Maojun,Shao, Guoqing. 2013

[5]The swine CD81 enhances E2-based DNA vaccination against classical swine fever. Li, Wenliang,Zhou, Bin,Liu, Xia,Yang, Leilei,Zhang, Wenwen,Jiang, Jieyuan,Zhou, Bin.

[6]Salidroside liposome formulation enhances the activity of dendritic cells and immune responses. Zhao, Xiaojuan,Tao, Yang,Huang, Yee,Wang, Deyun,Hu, Yuanliang,Liu, Jiaguo,Wu, Yi,Yu, Yun,Liu, Cui,Zhao, Xiaojuan,Lu, Yu. 2013

[7]Antigen-Sparing and Enhanced Efficacy of Multivalent Vaccines Adjuvanted with Immunopotentiators in Chickens. Wu, Peipei,Lu, Jihu,Feng, Lei,Zhang, Xuehua,Mei, Mei,Hou, Jibo,Tang, Yinghua,Wu, Peipei,Lu, Jihu,Feng, Lei,Zhang, Xuehua,Mei, Mei,Hou, Jibo,Tang, Yinghua,Wu, Peipei,Lu, Jihu,Feng, Lei,Zhang, Xuehua,Mei, Mei,Hou, Jibo,Liu, Xiufan,Tang, Yinghua,Wu, Hongzhuan,Liu, Xiufan. 2017

[8]An inactivated gE-deleted pseudorabies vaccine provides complete clinical protection and reduces virus shedding against challenge by a Chinese pseudorabies variant. Wang, Jichun,Guo, Rongli,Qiao, Yongfeng,Xu, Mengwei,Wang, Zhisheng,Liu, Yamei,Gu, Yiqi,Liu, Chang,Hou, Jibo,Gu, Yiqi,Liu, Chang,Wang, Jichun,Guo, Rongli,Qiao, Yongfeng,Xu, Mengwei,Wang, Zhisheng,Liu, Yamei,Hou, Jibo. 2016

[9]CTA1: Purified and display onto gram-positive enhancer matrix (GEM) particles as mucosal adjuvant. Zhang, Yuanpeng,Yu, Xiaoming,Hou, Liting,Chen, Jin,Li, Pengcheng,Qiao, Xuwen,Zheng, Qisheng,Hou, Jibo,Zhang, Yuanpeng,Yu, Xiaoming,Hou, Liting,Chen, Jin,Li, Pengcheng,Qiao, Xuwen,Zheng, Qisheng,Hou, Jibo,Zhang, Yuanpeng,Yu, Xiaoming,Hou, Liting,Chen, Jin,Li, Pengcheng,Qiao, Xuwen,Zheng, Qisheng,Hou, Jibo. 2018

[10]Effects of Mycoplasma hyopneumoniae on porcine nasal cavity dendritic cells. Shen, Yumeng,Hu, Weiwei,Yang, Qian,Wei, Yanna,Feng, Zhixin.

[11]In vitro protective efficacy of Lithium chloride against Mycoplasma hyopneumoniae infection. Ishag, Hassan Z. A.,Wu, Yu-zi,Liu, Mao-jun,Xiong, Qi-yan,Feng, Zhi-xin,Yang, Ruo-song,Shao, Guo-qing,Ishag, Hassan Z. A..

[12]Transcription analysis on response of porcine alveolar macrophages to co-infection of the highly pathogenic porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae. Li, Bin,Du, Luping,Xu, Xiangwei,Sun, Bing,Yu, Zhengyu,Feng, Zhixin,Liu, Maojun,Wei, Yanna,Wang, Haiyan,Shao, Guoqing,He, Kongwang,Li, Bin,Yu, Zhengyu,Feng, Zhixin,Liu, Maojun,Wei, Yanna,Wang, Haiyan,Shao, Guoqing,He, Kongwang.

[13]The effects of Mycoplasma hyopneumoniae on porcine circovirus type 2 replication in vitro PK-15 cells. Wang, Haiyan,Feng, Zhixin,Wu, Yuzi,Wei, Yanna,Gan, Yuan,Hua, Lizhong,Li, Bin,Wang, Xiaomin,Liu, Maojun,Xiong, Qiyan,Shao, Guoqing,Wang, Haiyan,Feng, Zhixin,Shao, Guoqing.

[14]Development of a blocking ELISA for detection of Mycoplasma hyopneumoniae infection based on a monoclonal antibody against protein P65. Liu, Maojun,Zhang, Yue,Wu, Yuzi,Wang, Haiyan,Li, Bin,Bai, Yun,Feng, Zhixin,Xiong, Qiyan,Bai, Fangfang,Shao, Guoqing,Liu, Maojun,Du, Gaimei,Browning, Glenn F.,Shao, Guoqing.

[15]Comparative analysis of mucosal immunity to Mycoplasma hyopneumoniae in Jiangquhai porcine lean strain and DLY piglets. Hua, L. Z.,Wu, Y. Z.,Bai, F. F.,William, K. K.,Feng, Z. X.,Liu, M. J.,Yao, J. T.,Zhang, X.,Shao, G. Q.. 2014

[16]A rapid and sensitive loop-mediated isothermal amplification procedure (LAMP) for Mycoplasma hyopneumoniae detection based on the p36 gene. Liu, M. J.,Du, G. M.,Bai, F. F.,Wu, Y. Z.,Xiong, Q. Y.,Feng, Z. X.,Li, B.,Shao, G. Q.,Du, G. M.,Liu, M. J.,Shao, G. Q.. 2015

[17]A replicating plasmid-based vector for GFP expression in Mycoplasma hyopneumoniae. Ishag, H. Z. A.,Liu, M. J.,Yang, R. S.,Xiong, Q. Y.,Feng, Z. X.,Shao, G. Q.,Ishag, H. Z. A.. 2016

[18]Development and validation of an attenuated Mycoplasma hyopneumoniae aerosol vaccine. Feng, Zhi-Xin,Wei, Yan-Na,Li, Gui-Lan,Lu, Xiao-Ming,Wang, Zhan-Wei,Kong, Meng,Gan, Yuan,Bai, Fang-Fang,Liu, Mao-Jun,Xiong, Qi-Yan,Wu, Xu-Su,Shao, Guo-Qing,Wan, Xiu-Feng,Pharr, G. Todd. 2013

[19]Cholesterol exacerbates Mycoplasma hyopneumoniae-induced apoptosis via stimulating proliferation and adhesion to porcine alveolar macrophages. Liu, Maojun,Hu, Yun,Liu, Jie,Jia, Yimin,Zhao, Ruqian,Liu, Maojun,Liu, Beibei,Shao, Guoqing,Jia, Yimin,Zhao, Ruqian,Du, Gaimei,Minion, F. Chris,Shao, Guoqing. 2017

[20]Comparative genomic analyses of Mycoplasma hyopneumoniae pathogenic 168 strain and its high-passaged attenuated strain. Liu, Wei,Xiao, Shaobo,Li, Mao,Guo, Shaohua,Li, Sha,Luo, Rui,Chen, Huanchun,Fang, Liurong,Feng, Zhixin,Li, Bin,Shao, Guoqing,Zhou, Zhemin. 2013

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台