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Protective efficacy of a live attenuated Mycoplasma hyopneumoniae vaccine with an ISCOM-matrix adjuvant in pigs

文献类型： 外文期刊

作者： Xiong, Qiyan 1 ; Wei, Yanna 1 ; Feng, Zhixin 1 ; Gan, Yuan 1 ; Liu, Zhanjun 1 ; Liu, Maojun 1 ; Bai, Fangfang 2 ; Shao, G 1 ;

作者机构： 1.Natl Ctr Engn Res Vet Bioprod, Minist Agr, Key Lab Vet Biol Engn & Technol, Inst Vet Med,Jiangsu Acad Agr Sci, Nanjing 210014, Jiangsu, Peoples R China

2.Natl Ctr Engn Res Vet Bioprod, Minist Agr, Key Lab Vet Biol Engn & Technol, Inst Vet Med,Jiangsu Acad Agr

关键词： Pig;Adjuvant;Intramuscular vaccine;Mycoplasma hyopneumoniae

期刊名称：VETERINARY JOURNAL （ 影响因子：2.688； 五年影响因子：2.857 ）

ISSN：

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收录情况： SCI

摘要： An attenuated Mycoplasma hyopneumoniae vaccine that requires intrathoracic administration is commercially available for use against mycoplasmal pneumonia in China. Given the limitations of such a route of administration, this study was undertaken to assess the capacity of an ISCOM-matrix adjuvant to enhance immunogenicity following intramuscular use. Immune responses in pigs following vaccination and subsequent intra-tracheal bacterial inoculation were examined using lymphocyte proliferation, serology and mucosal IgA in both nasal and saliva swabs. Vaccination induced clear lymphocyte proliferation, but only slight serum antibody responses although these were significantly increased following experimental infection. Mucosal IgA was not detected in either nasal or salivary secretions. Following bacterial challenge, animals vaccinated with the adjuvant-containing live vaccine exhibited less severe pulmonary lesions (median score 3.67) than unvaccinated pigs (median score 13.58). The degree of ciliary loss on the respiratory tract surface was reduced in vaccinated pigs compared with experimentally infected controls. The findings indicated that the adjuvant vaccine administered IM provided protection against experimentally induced mycoplasmal pneumonia and could have commercial potential.

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