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Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway

文献类型： 外文期刊

作者： Liu, Jia 1 ; Zheng, Lanhong 2 ; Wu, Ning 1 ; Ma, Leina 4 ; Zhong, Jiateng 5 ; Liu, Ge 1 ; Lin, Xiukun 1 ;

作者机构： 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China

2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

3.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

4.Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China

5.Jilin Univ, Dept Pathophysiol, Norman Bethune Coll Med, Changchun 130021, Peoples R China

6.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China

关键词： aerobic glycolysis;AMPK;metabolism;oleanolic acid

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

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收录情况： SCI

摘要： Cancer cells are well-known to require a constant supply of protein, lipid, RNA, and DNA via altered metabolism for accelerated cell proliferation. Targeting metabolic pathways is, therefore, a promising therapeutic strategy for cancers. Oleanolic acid (OA) is widely distributed in dietary and medicinal plants and displays a selective cytotoxicity to cancer cells, primarily by inducing apoptosis and cell cycle arrest. This study investigated if OA inhibited growth of tumor cells by affecting their metabolism. OA was found to activate AMP-actiyated protein kinase (AMPK), the master regulator of metabolism, in prostate cancer cell line PC-3 and breast cancer cell line MCF-7. AMPK activation is required for the antitumor activity of OA on cancer cells. Lipogenesis, protein synthesis, and aerobic glycolysis were inhibited in cancer cells treated with OA, in an AMPK activation-dependent manner. The metabolic alteration was shown to mediate the tumor suppressor activity of OA on cancer cells. Collectively, this study provides evidence that OA, as a widely distributed nutritional component, is able to exert antitumor function by interfering in the metabolic pathway in cancer cells. This finding should encourage researchers to study if affecting cancer metabolism is a common mechanism by which nutritional compounds suppress cancers.

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[1]ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway. Liu, Jia,Ma, Leina,Chen, Xiao,Wang, Jianxun,Yu, Tao,Gong, Ying,Ma, Aiguo,Liang, Hui,Ma, Leina,Zheng, Lanhong. 2016

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[4]p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid. Liu, Jia,Wu, Ning,Liu, Ge,Lin, Xiu-Kun,Zheng, Lan-Hong,Ma, Lei-Na,Liu, Ge,Lin, Xiu-Kun,Zhong, Jia-Teng. 2014

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