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Enolase-based nanovaccine immersion immunization induces robust immunity and protection against Streptococcus infection in tilapia

文献类型： 外文期刊

作者： Liu, Jia 1 ; Cao, Ye 1 ; Ma, Haixiang 1 ; Du, Hui 1 ; Liu, Tianqiang 1 ; Wang, Gaoxue 1 ; Liu, Mingzhu 4 ; Wang, Qing 2 ; Li, Pengfei 4 ; Wang, Erlong 1 ;

作者机构： 1.Northwest A&F Univ, Shenzhen Res Inst, Shenzhen 518000, Guangdong, Peoples R China

2.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Aquat Anim Immune Technol, Key Lab Fishery Drug Dev,Minist Agr & Rural Affair, Guangzhou 510380, Guangdong, Peoples R China

3.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

4.Guangxi Acad Sci, Guangxi Acad Marine Sci, Guangxi Key Lab Aquat Biotechnol & Modern Ecol Aqu, Nanning, Peoples R China

关键词： Streptococcus; Enolase; Nanovaccine; Immunoprotective effect; Tilapia

期刊名称：AQUACULTURE （ 影响因子：4.5； 五年影响因子：4.6 ）

ISSN： 0044-8486

年卷期： 2023 年 576 卷

页码：

收录情况： SCI

摘要： Streptococcal disease is one of the most serious diseases in tilapia, causing huge economic losses to the tilapia farming industry. Streptococcus agalactiae (S. agalactiae) and Streptococcus iniae (S. iniae) are the two main pathogens of tilapia streptococcosis. Vaccination has been proved to be an effective measure to control fish bacterial diseases. In this study, we selected the Enolase (Eno) as the candidate vaccine antigen, which is the common antigen of S. agalactiae and S. iniae with high similarity (97.2%), the rEno was obtained and the CNTrEno nanocarrier vaccine system was constructed by connecting the rEno protein with functionalized carbon nanotubes (CNTs), the immersion immune effect against S. agalactiae and S. iniae infection was evaluated. The results showed that, compared with the control group, CNT-rEno significantly enhanced the serum antibody production, related enzyme activities and immune-related genes expression. It was worth noting that CNT-rEno demonstrated better immunoprotection against S. agalactiae and S. iniae infection, with relative percent survivals of 73.68% (S. agalactiae) and 68.96% (S. iniae), respectively, which were both much higher than those of rEno groups (36.84% and 31.03%, respectively). Our study indicated that the CNT-rEno nanovaccine had the ability to elicit robust immune responses in tilapia by immersion immunization, and had the potential to offer crossprotection against S. agalactiae and S. iniae infection.

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