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Exploring the Immunoprotective Potential of a Nanocarrier Immersion Vaccine Encoding Sip against Streptococcus Infection in Tilapia (Oreochromis niloticus)

文献类型： 外文期刊

作者： Cao, Ye 1 ; Liu, Jia 2 ; Liu, Gaoyang 2 ; Du, Hui 2 ; Liu, Tianqiang 2 ; Wang, Gaoxue 2 ; Wang, Qing 1 ; Zhou, Ya 4 ; Wang, Erlong 2 ;

作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Aquat Anim Immune Technol, Key Lab Fishery Drug Dev,Minist Agr & Rural Affair, Guangzhou 510380, Guangdong, Peoples R China

2.Northwest A&F Univ, Shenzhen Res Inst, Shenzhen 518000, Peoples R China

3.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Peoples R China

4.Chongqing Three Gorges Vocat Coll, Coll Anim Sci & Technol, Chongqing 404155, Peoples R China

关键词： Streptococcus; surface immunogenic protein; immersion immunization; Tilapia

期刊名称：VACCINES （ 影响因子：7.8； 五年影响因子：7.4 ）

ISSN：

年卷期： 2023 年 11 卷 7 期

页码：

收录情况： SCI

摘要： Tilapia, as one of the fish widely cultured around the world, is suffering severe impact from the streptococcus disease with the deterioration of the breeding environment and the increasing of breeding density, which brings serious economic loss to tilapia farming. In this study, the surface immunogenic protein (Sip) of Streptococcus agalactiae (S. agalactiae) was selected as the potential candidate antigen and connected with bacterial nano cellulose (BNC) to construct the nanocarrier subunit vaccine (BNC-rSip), and the immersion immune effects against S. agalactiae and Streptococcus iniae (S. iniae) in Nile tilapia were evaluated on the basis of the serum antibody level, non-specific enzyme activity, the immune-related gene expression and relative percent survival (RPS). The results indicated that Sip possessed the expected immunogenicity according to the immunoinformatic analysis. Compared with the rSip group, BNC-rSip significantly induced serum antibody production and improved the innate immunity level of tilapia. After challenge, the RPS of BNC-rSip groups were 78.95% (S. agalactiae) and 67.86% (S. iniae), which were both higher than those of rSip groups,31.58% (S. agalactiae) and 35.71% (S. iniae), respectively. Our study indicated that BNC-rSip can induce protective immunity for tilapia through immersion immunization and may be an ideal candidate vaccine for controlling tilapia streptococcal disease.

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