Exploring the Immunoprotective Potential of a Nanocarrier Immersion Vaccine Encoding Sip against Streptococcus Infection in Tilapia (Oreochromis niloticus)
文献类型： 外文期刊
作者： Cao, Ye 1 ; Liu, Jia 2 ; Liu, Gaoyang 2 ; Du, Hui 2 ; Liu, Tianqiang 2 ; Wang, Gaoxue 2 ; Wang, Qing 1 ; Zhou, Ya 4 ; Wang, Erlong 2 ;
作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Aquat Anim Immune Technol, Key Lab Fishery Drug Dev,Minist Agr & Rural Affair, Guangzhou 510380, Guangdong, Peoples R China
2.Northwest A&F Univ, Shenzhen Res Inst, Shenzhen 518000, Peoples R China
3.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Peoples R China
4.Chongqing Three Gorges Vocat Coll, Coll Anim Sci & Technol, Chongqing 404155, Peoples R China
关键词： Streptococcus; surface immunogenic protein; immersion immunization; Tilapia
期刊名称：VACCINES （ 影响因子：7.8； 五年影响因子：7.4 ）
ISSN：
年卷期： 2023 年 11 卷 7 期
页码：
收录情况： SCI
摘要： Tilapia, as one of the fish widely cultured around the world, is suffering severe impact from the streptococcus disease with the deterioration of the breeding environment and the increasing of breeding density, which brings serious economic loss to tilapia farming. In this study, the surface immunogenic protein (Sip) of Streptococcus agalactiae (S. agalactiae) was selected as the potential candidate antigen and connected with bacterial nano cellulose (BNC) to construct the nanocarrier subunit vaccine (BNC-rSip), and the immersion immune effects against S. agalactiae and Streptococcus iniae (S. iniae) in Nile tilapia were evaluated on the basis of the serum antibody level, non-specific enzyme activity, the immune-related gene expression and relative percent survival (RPS). The results indicated that Sip possessed the expected immunogenicity according to the immunoinformatic analysis. Compared with the rSip group, BNC-rSip significantly induced serum antibody production and improved the innate immunity level of tilapia. After challenge, the RPS of BNC-rSip groups were 78.95% (S. agalactiae) and 67.86% (S. iniae), which were both higher than those of rSip groups,31.58% (S. agalactiae) and 35.71% (S. iniae), respectively. Our study indicated that BNC-rSip can induce protective immunity for tilapia through immersion immunization and may be an ideal candidate vaccine for controlling tilapia streptococcal disease.
- 相关文献
作者其他论文 更多>>
-
Application of microalgae in remediation of heavy metal-contaminated soils and its stimulatory effect on wheat growth
作者：Liu, Jia;Liu, Yajing;Jiang, Han;Yang, Xiaokun;Wu, Yukun;Liang, Chengwei;Zhang, Xiaowen;Ye, Naihao;Zhang, Xiaowen;Ye, Naihao
关键词：Microalgae; Heavy metal-contaminated soils; Bioremediation; Soil fertility; Wheat growth
-
Cyprinid herpesvirus 3 replication is inhibited via decreased ORF3 promoter activity mediated by multiple cellular transcription factors
作者：Liu, Donghai;Wang, Yingying;Li, Yingying;Mo, Xubing;Yin, Jiyuan;Wang, Qing;Zheng, Shucheng;Liu, Donghai
关键词：Cyprinid herpesvirus 3; Koi herpesvirus; ORF3; Promoter; Transcription factors
-
Enhanced virulence of Acinetobacter johnsonii at low temperatures induces acute immune response and systemic infection in American bullfrogs (Aquarana catesbeiana)
作者：Lin, Han;Sun, Jingyang;Li, Hua;Chen, Kesong;Qin, Zhendong;Jiang, Biao;Li, Wei;Su, Youlu;Lin, Li;Liu, Chun;Wang, Qing;Wang, Qing
关键词：Cold stress; Virulence genes; Amphibian disease; Immune response; Systemic infection
-
Dual impacts of elevated pCO2 on the ecological effects induced by microplastics and nanoplastics: A study with Chlamydomonas reinhardtii
作者：Liang, Chengwei;Liu, Yajing;Xi, Tianle;Liu, Jia;Jia, Zhihua;Liang, Chengwei;Ge, Shanshan;Zhang, Xiaowen;Ye, Naihao;Zhang, Xiaowen;Ye, Naihao
关键词：Micro-and nanoplastics; and nanoplastics; Freshwater acidification; Combined toxicity; Mechanisms; Oxidative stress; Chlamydomonas reinhardtii
-
Frog virus 3: Prevalence survey and quantitative analysis in American bullfrogs using TaqMan MGB probe real-time fluorescence quantitative PCR
作者：Li, Hua;Liu, Xiaobing;Sun, Jingyang;Lin, Han;Chen, Kesong;Hu, Yueming;Jiang, Mengzhen;Jiang, Biao;Li, Wei;Su, Youlu;Liu, Chun;Wang, Qing;Wang, Qing
关键词：Aquarana catesbeiana; Frog virus 3; TaqMan-MGB real-time PCR; Virus load; Prevalence survey
-
Enhanced stability and rheological properties of myofibrillar proteins emulsions conferred by oat β-glucan: Insights into structural and interfacial interactions
作者：Wu, Yanyan;Wu, Yamei;Zhao, Yongqiang;Xiang, Huan;Wang, Yueqi;Wu, Yanyan;Zhao, Yongqiang;Wang, Yueqi;Wu, Yamei;Hao, Zhiming;Wang, Qing
关键词：Oat beta-glucan; Myofibrillar protein; Conformational features; Interfacial property; Rheological property
-
Biological Characterization and Glucosinolate Degradation Mechanisms of Bacillus subtilis BSY82 in Rapeseed Meal
作者：Lu, Hong-yu;Shi, An-Ning;Liu, Li-Juan;Tang, Jiang-Yi;Wang, Ya-Jun;Zhang, De-Feng;Wang, Qing;Wang, Jun;Zhu, Xue-Zhi;Liu, Li-Yan
关键词：
Bacillus subtilis strain BSY82; biological characterization; fermented; glucosinolate; rapeseed meal
