Pharmacokinetics of doxycycline in tilapia (Oreochromis aureus x Oreochromis niloticus) after intravenous and oral administration
文献类型： 外文期刊
作者： Yang, F. 1 ; Li, Z. L. 2 ; Shan, Q. 3 ; Zeng, Z. L. 2 ;
作者机构： 1.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Luoyang, Peoples R China
2.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China
3.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Guangzhou, Guangdong, Peoples R China
期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）
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收录情况： SCI
摘要： The pharmacokinetics of doxycycline was studied in plasma after a single dose (20 mg/kg) of intravenous or oral administration to tilapia (Oreochromis aureus 9 Oreochromis niloticus) reared in fresh water at 24 degrees C. Plasma samples were collected from six fish per sampling point. Doxycycline concentrations were determined by high-performance liquid chromatography with a 0.005 mu g/mL limit of detection, then were subjected to noncompartmental analysis. Following oral administration, the double-peak phenomenon was observed, and the first (C-max1) and second (C-max2) peaks were 1.99 +/- 0.43 mu g/mL at 2.0 h and 2.27 +/- 0.38 mu g/mL at 24.0 h, respectively. After the intravenous injection, a C-max2 (12.12 +/- 1.97 mu g/mL) was also observed, and initial concentration of 45.76 mu g/mL, apparent elimination rate constant (lambda(z)) of 0.018 per h, apparent elimination half-life (t(1/2 lambda z)) of 39.0 h, systemic total body clearance (Cl) of 41.28 mL/h/kg, volume of distribution (Vz) of 2323.21 mL/kg, and volume of distribution at steady-state (Vss) of 1356.69 mL/kg were determined, respectively. While after oral administration, the lambda(z), t(1/2 lambda z), and bioavailability of doxycycline were 0.009 per h, 77.2 h, and 23.41%, respectively. It was shown that doxycycline was relatively slowly and incompletely absorbed, extensively distributed, and slowly eliminated in tilapia, in addition, doxycycline might undergo enterohepatic recycling in tilapia
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