文献类型： 外文期刊
作者： Cheng, Zhong-Bin 1 ; Liao, Qiong 1 ; Chen, Ye 1 ; Fan, Cheng-Qi 3 ; Huang, Zhi-Ying 1 ; Xu, Xin-Jun 1 ; Yin, Sheng 1 ;
作者机构： 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Ctr Lab Anim, Guangzhou 510006, Guangdong, Peoples R China
3.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China
关键词： cembranoids;coral Sarcophyton;recognized
期刊名称：MAGNETIC RESONANCE IN CHEMISTRY （ 影响因子：2.447； 五年影响因子：1.925 ）
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收录情况： SCI
摘要： Soft corals belonging to the genus Sarcophyton have been well recognized as a rich source of secondary metabolites endowed with a range of structural diversity and various biological activities. Members of this genus have been studied widely, resulting in the identification of unprecedented diterpenoids[1-3] and steroids.[4] Some of these metabolites are of considerable interest and merit continuous attention due to their unique structures and significant biological activities, including inhibition of protein tyrosine phosphatase 1B,[2] anti-tumor,[3] antimicrobial,[4] and anti-inflammatory properties.[5] As part of our continuing efforts to discover structurally intriguing biologically significant metabolites from marine invertebrates of the South China Sea,[6,7] we undertook a detailed chemical analysis of Sarcophyton sp., which led to the isolation of four new cembranoids (1-4), together with eight known compounds including five cembranoids (5-9), two carotenoids (10-11), and a tetra-substituted quinone (12) (Fig. 1). Herein, the details of the isolation, structure elucidation, and activity of these compounds are described.
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