Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo
文献类型： 外文期刊
作者： Sun, Zhang-Hua 1 ; Cai, Ying-Hong 1 ; Fan, Cheng-Qi 2 ; Tang, Gui-Hua 1 ; Luo, Hai-Bin 1 ; Yin, Sheng 1 ;
作者机构： 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
2.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China
关键词： gorgonian;Echinogorgia pseudossapo;tetraprenylated alkaloids;phosphodiesterases
期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）
ISSN： 1660-3397
年卷期： 2014 年 12 卷 2 期
页码：
收录情况： SCI
摘要： Six new tetraprenylated alkaloids, designated as malonganenones L-Q (1-6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1-6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1-6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC50 values of 8.5 and 20.3 mu M, respectively.
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