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Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba

文献类型： 外文期刊

作者： Cheng, Zhong-Bin 1 ; Xiao, Han 1 ; Fan, Cheng-Qi 2 ; Lu, Ya-Nan 2 ; Zhang, Ge 1 ; Yin, Sheng 1 ;

作者机构： 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

2.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China

关键词： Polyhydroxylated sterols;Structure elucidation;Antibacterial activity;Haliclona crassiloba

期刊名称：STEROIDS （ 影响因子：2.668； 五年影响因子：2.692 ）

ISSN： 0039-128X

年卷期： 2013 年 78 卷 14 期

页码：

收录情况： SCI

摘要： Four new polyhydroxylated sterols, named halicrasterols A-D (1-4), together with six known analogs (5-10) were isolated from the marine sponge Haliclona crassiloba. Compounds 1 and 2 represented rare examples of steroids featuring 17(20)E-double bonds. The structures of 1-10 were elucidated by spectroscopic analysis and comparison with reported data. This is the first report of a steroid profile for this species. The antimicrobial activities of 1-10 were evaluated against a panel of bacterial and fungal strains in vitro, and compounds 4 and 9 showed moderate activity against some of the Gram-positive strains with MICs ranging from 4 to 32 mu g/mL. (C) 2013 Elsevier Ltd. All rights reserved.

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