浙江省农业科学院机构知识库

Cloning and characterization of the mouse JDP2 gene promoter reveal negative regulation by p53

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文献类型：外文期刊

作者： Xu, Yuanhong ¹ ; Jin, Chunyuan ² ; Liu, Zhe ¹ ; Pan, Jianzhi ³ ; Li, Hongjie ² ; Zhang, Zhongbo ¹ ; Bi, Shulong ¹ ; Yokoy ¹ ;

作者机构： 1.China Med Univ, Hosp 1, Dept Pancreat Gastroenterol Surg, Shenyang 110001, Peoples R China

2.NYU, Sch Med, Dept Environm Med, Tuxedo Pk, NY 10987 USA

3.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet, Hangzhou, Zhejiang, Peoples R China

4.Kaohsiung Med Univ, Grad Inst Med, Kaohsiung 807, Taiwan

关键词： JDP2;p53;Promoter;Transcriptional regulation

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （影响因子：3.575；五年影响因子：3.381 ）

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收录情况： SCI

摘要： Jun dimerization protein 2 (JDP2) is a repressor of transcription factor AP-1. To investigate the transcriptional regulation of the JDP2 gene, we cloned the 5′-flanking region of the mouse JDP2 gene. Primer extension analysis revealed a new transcription start site (+1). Promoter analysis showed that the region from nt -343 to nt +177 contains basal transcriptional activity. Interestingly, the tumor suppressor p53 significantly repressed the transcriptional activity of the JDP2 promoter. Given that JDP2 inhibits expression of p53, our results suggest a negative feedback loop between JDP2 and p53, and a direct link between JDP2 and a key oncogenic pathway.

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