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Monacolin K production by citrinin-free Monascus pilosus MS-1 and fermentation process monitoring

文献类型： 外文期刊

作者： Feng, Yanli 1 ; Shao, Yanchun 1 ; Zhou, Youxiang 3 ; Chen, Fusheng 2 ;

作者机构： 1.Huazhong Agr Univ, Key Lab Environm Correlat Dietol, Minist Educ, Wuhan 430070, Hubei Province, Peoples R China

2.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei Province, Peoples R China

3.Hubei Acad Agr Sci, Inst Qual Standard & Testing Technol Agroprod, Wuhan, Hubei Province, Peoples R China

关键词： Hypocholesterolemic agents;Liquid-state fermentation;Mycotoxin contamination;Pharmaceutical process monitoring;Response surface methodology

期刊名称：ENGINEERING IN LIFE SCIENCES （ 影响因子：2.678； 五年影响因子：2.704 ）

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收录情况： SCI

摘要： Monacolin K (MK) is a naturally occurring hypocholesterolemic agent that specifically inhibits HMG-CoA reductase. As a natural source of MK, Monascus-fermented products are of special interest; however, some Monascus strains could produce citrinin, which is a nephrotoxin, as a contaminant in Monascus-derived products. A Monascus pilosus strain (MS-1) that produces high amounts of MK, but no citrinin, was screened in previous investigations. Herein, liquid-state fermentation parameters of the MS-1 strain were optimized using statistical methods to maximize the MK yield with potato juice as a basic medium. The maximum MK yield (326.74g/mL) was predicted with 50 mL of medium in a 250-mL conical flask containing 30 g/L sucrose, 38.75 g/L soybean flour, 0.00105 mol/L Mg2+ at pH 5.48, and 8% v/v seed inoculum precultured for 42 h at 30 degrees C, incubated at 30 degrees C for 3 days, followed by further incubation for 11 days at 24.7 degrees C. The verified MK yield was 390.68g/mL and the MK yield increased to 565.64g/mL after 21 days of fermentation. No citrinin was detected in MS-1-fermented products. The results suggest that citrinin-free MK can be obtained from natural medium through liquid-state fermentation in an economical way. This method will be of practical value to the industrial production of MK.

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