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Equine hyperimmune serum protects mice against Clostridium difficile spore challenge

文献类型： 外文期刊

作者： Yan, Weiwei 1 ; Shin, Kang-Soon 1 ; Wang, Shih-Jon 1 ; Xiang, Hua 1 ; Divers, Thomas 2 ; McDonough, Sean 3 ; Bowman, J 1 ;

作者机构： 1.Cornell Univ, Coll Vet Med, Anim Hlth Diagnost Ctr, Dept Populat Med & Diagnost Sci, Ithaca, NY 14853 USA

2.Cornell Univ, Coll Vet Med, Dept Clin Sci, Ithaca, NY 14853 USA

3.Cornell Univ, Coll Vet Med, Dept Biomed Sci, Ithaca, NY 14853 USA

4.Chang Jung Christian Univ, Dept Biosci Technol, Tainan 71101, Taiwan

5.Guangdong Acad Agr Sci, Vet Inst, Guangzhou 510640, Guangdong, Peoples R

关键词： Clostridium difficile;colitis;equine;immunotherapy

期刊名称：JOURNAL OF VETERINARY SCIENCE （ 影响因子：1.672； 五年影响因子：1.904 ）

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收录情况： SCI

摘要： Clostridium (C.) difficile is a common cause of nosocomial diarrhea in horses. Vancomycin and metronidazole have been used as standard treatments but are only moderately effective, which highlights the need for a novel alternative therapy. In the current study, we prepared antiserum of equine origin against both C. difficile toxins A and B as well as whole-cell bacteria. The toxin-neutralizing activities of the antibodies were evaluated in vitro and the prophylactic effects of in vivo passive immunotherapy were demonstrated using a conventional mouse model. The data demonstrated that immunized horses generated antibodies against both toxins A and B that possessed toxin-neutralizing activity. Additionally, mice treated with the antiserum lost less weight without any sign of illness and regained weight back to a normal range more rapidly compared to the control group when challenged orally with 107 C. difficile spores 1 day after serum injection. These results indicate that intravenous delivery of hyperimmune serum can protect animals from C. difficile challenge in a dose-dependent manner. Hence, immunotherapy may be a promising prophylactic strategy for preventing C. difficile infection in horses.

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