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An Unstructured Kinetic Model for the Improvement of Triterpenes Production by Ganoderma lucidum G0119 Based on Nitrogen Source Effect

文献类型： 外文期刊

作者： Feng, Jie 1 ; Zhang, Jing-Song 1 ; Jia, Wei 1 ; Yang, Yan 1 ; Liu, Fang 2 ; Lin, Chi-Chung;

作者机构： 1.Shanghai Acad Agr Sci, Key Lab Edible Fungi Resources & Utilizat South, Natl Engn Res Ctr Edible Fungi,Inst Edible Fungi, Minist Agr,Key Lab Agr Genet & Breeding Shanghai, Shanghai 201403, Peoples R China

2.Shanghai Acad Agr Sci, Key Lab Edible Fungi Resources & Utilizat South, Natl Engn Res Ctr Edible Fungi,Inst Edible Fungi, Minist Agr,Key Lab Agr Genet & Breeding Shanghai, Shanghai 201403, Peoples R C

关键词： Ganoderma lucidum;fermentation;kinetic model;kinetic parameters;genetic algorithms;triterpene

期刊名称：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING （ 影响因子：2.836； 五年影响因子：2.281 ）

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收录情况： SCI

摘要： The kinetics of cell growth and triterpenes production for liquid submerged fermentation of the medicinal mushroom Ganoderma lucidum were investigated. A kinetic model was developed based on the Logistic and Luedeking-Piret equations for cell growth, substrate consumption and triterpene formation. The kinetic parameters of the model were optimized by specifically designed Runge-Kutta genetic algorithms. The mathematical model simulated the experimental data well and was capable of explaining the behavior of triterpenes production. The predictions of the kinetics from this model are very good both for normal fermentation kinetics under nitrogen limitation as well as for predictions of transitions to sluggish fermentations. The resulting model is very useful for scaling up liquid submerged fermentation of the mushroom G. lucidum and its application to the industrial production of triterpene.

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