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Microarray analysis of differentially expressed gene responses to bisphenol A in Arabidopsis

文献类型： 外文期刊

作者： Tian, Yong-Sheng 1 ; Jin, Xiao-Fen 1 ; Fu, Xiao-Yan 1 ; Zhao, Wei 1 ; Han, Hong-Juan 1 ; Zhu, Bo 1 ; Man-Liu 2 ; Yao, Qua 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Biotechnol Res Inst, Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China

2.Shanghai Ruifeng Agr Sci & Technol Co Ltd, Shanghai 201106, Peoples R China

关键词： Arabidopsis;BPA;Microarray;RT-PCR;Toxicity

期刊名称：JOURNAL OF TOXICOLOGICAL SCIENCES （ 影响因子：2.196； 五年影响因子：2.177 ）

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年卷期：

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收录情况： SCI

摘要： Environmental levels of bisphenol A (BPA) are a global concern because the compound can cause damage to reproductive organs, the thyroid gland, and brain tissues at developmental stages. Plants are important in removing BPA from the atmosphere, soil, and water. However, knowledge on the mechanism by which plants respond to this compound is limited. To determine the response mechanism of plants to BPA, we used a microarray system to analyze the gene expression patterns of Arabidopsis thaliana after irrigation with 3.0 mM BPA. We identified 651 genes that were differentially expressed upregulated and 470 genes that were downregulated by BPA. These genes may specifically contribute to BPA uptake, transformation, conjugation, and compartmentation in plants. The potential function of upregulated genes in plant defense against BPA was also determined.

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