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Evaluation on Activity of Cytochrome P450 Enzymes in Turbot Via a Probe Drug Cocktail

文献类型： 外文期刊

作者： Chang, Zhi-Qiang 1 ; Li, Jian 1 ; Zhai, Qian-Qian 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Dev Marine Fisheries, Minist Agr, Qingdao 266071, Peoples R China

期刊名称：JOURNAL OF AQUATIC ANIMAL HEALTH （ 影响因子：1.625； 五年影响因子：1.786 ）

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收录情况： SCI

摘要： Cytochrome P450s (CYPs) are the main catalytic enzymes formetabolism by a variety of endogenous and exogenous substrates in mammals, fish, insects, etc. We evaluated the application of a multidrug cocktail on changes in CYP1, CYP2, and CYP3 activity in Turbot Scophthalmus maximus. The probe drugs were a combination of caffeine (5 mg/kg body weight), dapsone (5 mg/kg), and chlorzoxazone (10 mg/kg). After a single intraperitoneal injection of the cocktail, the concentration of all three probe drugs in the plasma increased quickly to a peak and then decreased gradually over 24 h. Pharmacokinetic profiles of the three probe drugs were determined using a noncompartmental analysis, and the typical parameters were calculated. In the assay for CYP induction, pretreatment with rifampicin significantly reduced the typical pharmacokinetic metrics for caffeine and chlorzoxazone, but not dapsone, indicating that the activity of CYP1 and CYP2 in turbot were induced by rifampicin.

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