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Alteration of the miRNA expression profile in male porcine anterior pituitary cells in response to GHRH and CST and analysis of the potential roles for miRNAs in regulating GH

文献类型： 外文期刊

作者： Qi, Qi-En 1 ; Xi, Qian-Yun 1 ; Ye, Rui-Song 1 ; Chen, Ting 1 ; Cheng, Xiao 1 ; Li, Chao-Yun 1 ; Zhu, Xiao-Tong 1 ; Shu, G 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China

2.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed

关键词： Porcine;Pituitary;Growth hormone;miRNA

期刊名称：GROWTH HORMONE & IGF RESEARCH （ 影响因子：2.372； 五年影响因子：2.362 ）

ISSN：

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收录情况： SCI

摘要： Objective: Growth hormone releasing hormone (GHRH) is a major positive regulator of growth hormone (GH) in the anterior pituitary gland, while cortistatin's (CST) role is negative. miRNAs (microRNAs or miRs) are small RNA molecules modulating gene expression at the post-transcriptional level. However, little is known about the function of miRNAs in the regulation of GH synthesis and/or secretion. This study investigated potential functional miRNAs involved in GH secretion in the normal porcine pituitary.

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