Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821
文献类型： 外文期刊
作者： Wan, Zhongyi 1 ; Fang, Wei 2 ; Shi, Liqiao 2 ; Wang, Kaimei 2 ; Zhang, Yani 2 ; Zhang, Zhigang 2 ; Wu, Zhaoyuan 2 ; Yang, 1 ;
作者机构： 1.Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China
2.Hubei Acad Agr Sci, Natl Engn Res Ctr Biopesticide, Wuhan 430064, Peoples R China
3.Syngenta Jealotts Hill Int Res Ctr, Bracknell, Berks, England
期刊名称：JOURNAL OF ANTIBIOTICS （ 影响因子：2.649； 五年影响因子：2.772 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Two new 32- membered macrolide compounds, named Novonestmycins A ( 1) and B ( 2), were isolated from the soil strain Streptomyces phytohabitans HBERC-20821. Their structures were elucidated by using spectroscopic methods, including 1D, 2D-NMR and MS spectrometry. The two compounds showed strong activities against the phytophathogenic fungi Corynespora cassiicola, Rhizoctonia solani and Septoria nodorum, with MIC values of 0.78, 0.39 and 0.78 mu gml(-1), respectively. In addition, the two compounds exhibited potent inhibitory activities against four different human tumor cell lines as well as one 5- FU- resistant human hepatocellular carcinoma cell line, with IC50 of 0.15-0.48 mu g ml(-1) and 0.24-1.34 mu g ml(-1), respectively.
- 相关文献
作者其他论文 更多>>
-
Natural Furan-Carboxylic Acid (HHCA) and Its Derivatives: Synthesis, Characterization, Bioevaluation, and Structure-Activity Relationships as Potential Fungicidal Agents
作者：Guo, Lirong;Wang, Hexiang;Zheng, Fuqiang;Liu, Fang;Zhang, Zhigang;Wang, Kaimei;Bao, Longzhu;Ke, Shaoyong;Guo, Lirong;Wang, Hexiang;Xu, Shiyu;Cao, Xiufang;Zheng, Fuqiang;Huang, Wenbo
关键词：natural product; HHCA; structural diversity; antifungal activity; SARs
-
Three new naphthoquinone-based meroterpenoids from Streptomyces sp. HBERC-16614 with antibacterial activities
作者：Zhang, Ya-Ni;Liu, Man-Li;Liu, Fang;Zhang, Zhi-Gang;Wu, Zhao-Yuan;Shi, Li-Qiao;Wan, Zhong-Yi;Wang, Yue-Ying;Zhang, Fei;Wang, Kai-Mei;Fang, Wei;Zhang, Ya-Ni;Liu, Man-Li;Liu, Fang;Zhang, Zhi-Gang;Wu, Zhao-Yuan;Shi, Li-Qiao;Wan, Zhong-Yi;Wang, Yue-Ying;Zhang, Fei;Wang, Kai-Mei;Fang, Wei
关键词：Naphthoquinone-based meroterpenoids; spironaphthomeroterpenoid; naphthablins D and E; antibacterial activities
-
Functional analysis of potential fumiquinazoline biosynthetic gene clusters in Penicillium digitatum of citrus
作者：Liu, Shuqi;Lu, Yongqing;Wang, Yuqing;Long, Chao-an;Long, Chao-an;Long, Chao-an;Fang, Wei
关键词：Penicillium digitatum; Secondary metabolites; Gene; Virulence
-
Unlocking the neuroprotective secrets of natural products: a focus on the gut-brain axis
作者：Yang, Xiliang;Hu, Die;Cheng, Ruoyan;Bao, Qianqian;Jiang, Huan;Zhao, Binjie;Zhang, Yani
关键词：Natural products; Chinese medicine prescriptions; Gut-brain axis; Neuroprotective activity; Neurodegenerative disease
-
From monomers to pentamers, diverse antimicrobial benzofuran polyketides from marine-derived Striaticonidium cinctum
作者：Chen, Chunmei;Cai, Jian;Chen, Yi;Yang, Bin;Liu, Yonghong;Zhou, Xuefeng;Chen, Chunmei;Cai, Jian;Chen, Yi;Yang, Bin;Liu, Yonghong;Zhou, Xuefeng;Yang, Chun;Tao, Huaming;Liu, Manli;Fang, Wei
关键词：
-
Natural pyrrolo[1,2-a]quinazolinone derivatives: Design, synthesis, characterization, and bio-evaluation as novel antiviral agents
作者：Wei, Yanhong;Zheng, Fuqiang;Chen, Wenxuan;Li, Ying;Alateng, W.;Su, Jianglong;Kong, Mengmeng;Zheng, Fuqiang;Guo, Lirong;Wang, Hexiang;Bao, Longzhu;Wu, Zhaoyuan;Ke, Shaoyong;Guo, Lirong;Wang, Hexiang
关键词：Natural product; Pyrrolo[1; a ]quinazolinone derivatives; Antiviral agents; EV71; CVB3
-
Peptidomimetics based on natural cinnamic acid scaffold: Synthesis, bio-evaluation and structure-activity relationships
作者：Guo, Lirong;Wang, Hexiang;Liu, Fang;Bao, Longzhu;Wu, Zhaoyuan;Ye, Ting;Zhang, Yani;Wang, Yueying;Fang, Wei;Ke, Shaoyong;Guo, Lirong;Wang, Hexiang;Cao, Xiufang;Duan, Liping;Duan, Liping;Duan, Liping;Duan, Liping
关键词：Natural product; Peptidomimetics; Cinnamic acid; Conjugates; Biological activity; SARs
