Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821
文献类型： 外文期刊
作者： Wan, Zhongyi 1 ; Fang, Wei 2 ; Shi, Liqiao 2 ; Wang, Kaimei 2 ; Zhang, Yani 2 ; Zhang, Zhigang 2 ; Wu, Zhaoyuan 2 ; Yang, 1 ;
作者机构： 1.Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China
2.Hubei Acad Agr Sci, Natl Engn Res Ctr Biopesticide, Wuhan 430064, Peoples R China
3.Syngenta Jealotts Hill Int Res Ctr, Bracknell, Berks, England
期刊名称：JOURNAL OF ANTIBIOTICS （ 影响因子：2.649； 五年影响因子：2.772 ）
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收录情况： SCI
摘要： Two new 32- membered macrolide compounds, named Novonestmycins A ( 1) and B ( 2), were isolated from the soil strain Streptomyces phytohabitans HBERC-20821. Their structures were elucidated by using spectroscopic methods, including 1D, 2D-NMR and MS spectrometry. The two compounds showed strong activities against the phytophathogenic fungi Corynespora cassiicola, Rhizoctonia solani and Septoria nodorum, with MIC values of 0.78, 0.39 and 0.78 mu gml(-1), respectively. In addition, the two compounds exhibited potent inhibitory activities against four different human tumor cell lines as well as one 5- FU- resistant human hepatocellular carcinoma cell line, with IC50 of 0.15-0.48 mu g ml(-1) and 0.24-1.34 mu g ml(-1), respectively.
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