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Characterization of Chinese giant salamander iridovirus tissue tropism and inflammatory response after infection

文献类型： 外文期刊

作者： Jiang, Nan 1 ; Fan, Yuding 1 ; Zhou, Yong 1 ; Liu, Wenzhi 1 ; Ma, Jie 1 ; Meng, Yan 1 ; Xie, Congxin 2 ; Zeng, Lingbing 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Div Fish Dis, Wuhan 430223, Hubei, Peoples R China

2.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

关键词： Chinese giant salamander;Iridovirus;Replication;Tissue tropism;Inflammatory response

期刊名称：DISEASES OF AQUATIC ORGANISMS （ 影响因子：1.802； 五年影响因子：2.148 ）

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收录情况： SCI

摘要： The Chinese giant salamander iridovirus (GSIV), belonging to the genus Ranavirus in the family Iridoviridae, causes severe hemorrhagic lesions and nearly 100% mortality in naturally infected Chinese giant salamanders Andrias davidiamus. However, the replication and distribution of the virus has not been well characterized in vivo. Using in situ hybridization, the expression of the GSIV major capsid protein (MCP) was detected in the cytoplasm of cells of the spleen, kidney, liver and gut tissues. MCP expression in the spleen and kidney appeared to fluctuate significantly during the acute phase of infection. Using an immunofluorescence assay, GSIV antigens were abundant in the spleen and kidney tissues but appeared to be at relatively low levels in the liver and gut. Additionally, there were significant changes in the expression of the pro-inflammatory cytokines macrophage migration inhibitory factor (MIF), tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) in different tissues in response to infection with GSIV. The expression of MIF, TNF-alpha and IL-1 beta had significantly increased in the spleen at 3 d post-infection; this correlated with a decrease in virus replication in the spleen. These results suggest that the spleen and kidney are the major target tissues of GSIV, and the increased expression of MIF, TNF-alpha and IL-1 beta may contribute to a reduction of virus replication in the spleen.

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[1]Immunological responses and protection in Chinese giant salamander Andrias davidianus immunized with inactivated iridovirus. Liu, Wenzhi,Xu, Jin,Ma, Jie,Meng, Yan,Fan, Yuding,Zhou, Yong,Zeng, Lingbing,Liu, Wenzhi,Zeng, Lingbing,LaPatra, Scott E.,Yang, Xin.

[2]Cloning, sequence analysis and expression profiles of Toll-like receptor 7 from Chinese giant salamander Andrias davidianus. Huang, Lili,Zeng, Lingbing,Fan, Yuding,Zhou, Yong,Jiang, Nan,Liu, Wenzhi,Meng, Yan,Zeng, Lingbing.

[3]Protective immunity of a Pichia pastoris expressed recombinant iridovirus major capsid protein in the Chinese giant salamander, Andrias davidianus. Zhou, Yong,Fan, Yuding,Ma, Jie,Xu, Jin,Meng, Yan,Jiang, Nan,Zeng, Lingbing,Zhou, Yong,LaPatra, Scott E..

[4]Vaccination with Recombinant Baculovirus Expressing Ranavirus Major Capsid Protein Induces Protective Immunity in Chinese Giant Salamander, Andrias davidianus. Zhou, Xiaoyuan,Zhang, Xinglang,Han, Yahui,Jia, Qiuhong,Gao, Hongwei. 2017

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