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Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents

文献类型: 外文期刊

作者: Ke, Shaoyong 1 ; Shi, Liqiao 1 ; Yang, Ziwen 1 ;

作者机构: 1.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China

关键词: Isatin;Dehydroepiandrosterone;Hybrids;Synthesis;Antitumor activity

期刊名称:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS ( 影响因子:2.823; 五年影响因子:2.677 )

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收录情况: SCI

摘要: A series of isatin-dehydroepiandrosterone hybrids were synthesised via a convenient condensation procedure, and which were evaluated for their potential anticancer activities. The preliminary assays indicated that some of the newly obtained compounds exhibited good antitumor activities against human hepatocellular liver carcinoma (HepG2), heptoma (Huh-7), melanoma (A875) and 5-fluorouracil-resistant human hepatocellular carcinoma (BEL-7402/5-FU) cell lines compared with 5-fluorouracil (5-FU), which might be considered as promising lead scaffold for further design and synthesis of highly potential anticancer agents. (C) 2015 Elsevier Ltd. All rights reserved.

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