Hypoglycemic Activity of Polysaccharide from Fruiting Bodies of the Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Higher Basidiomycetes), on Mice Induced by Alloxan and Its Potential Mechanism
文献类型: 外文期刊
作者: Zhou, Shuai 1 ; Liu, Yanfang 2 ; Yang, Yan 2 ; Tang, Qingjiu 2 ; Zhang, Jingsong 3 ;
作者机构: 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Key Lab Appl Mycol Resources, Natl Engn Res Ctr Edible Fungi, Shanghai 201403, Peoples R China
2.Shanghai Acad Agr Sci, Inst Edible Fungi, Key Lab Appl Mycol Resources, Natl Engn Res Ctr Edible Fungi, Shanghai 201403, Peoples R China; Shanghai Acad Agr Sci, Inst Edible Fungi, Minist Agr, Shanghai 201403, Peoples R China
3.Shanghai Acad Agr Sci, Inst Edible Fungi, Key Lab Appl Mycol Resources, Natl Engn Res Ctr Edible Fungi, Shanghai 201403, Peoples R China; Shanghai Acad Agr Sci, Inst Edible Fungi, Minist Agr, Shanghai 201403,
关键词: medicinal mushrooms;Coprinus comatus;fruiting body;polysaccharide;lymphocyte proliferation;hypoglycemic activity
期刊名称:INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS ( 影响因子:1.921; 五年影响因子:1.879 )
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收录情况: SCI
摘要: Three polysaccharide fractions from fruiting bodies of Coprinus comatus-CC30, CC60, and CC80-are obtained by water extraction and ethanol precipitation with ethanol percentages of 30%, 60%, and 80%, respectively. The hypoglycemic activity of the three fractions was tested based on mice with alloxan-induced diabetes. Results indicate that fraction CC60 is the most effective fraction in water extract from C. comatus; it can remarkably reduce the blood glucose concentration in 120 min at a dosage of 1000 mg/kg administered orally. It also presents a long-term hypoglycemic effect during 21 days of injection at the same dosage. This polysaccharide fraction provide a novel path to improve the treatment currently used for patients with diabetes. The data on mice spleen lymphocyte proliferation and protein tyrosine phosphatase 1B (PTP1B)-inhibiting activity of fractions indicate that the hypoglycemic activity of CC60 is possibly activated through immune stimulation, not PTP1B inhibition.
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