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Genome sequencing and analysis of a novel recombinant porcine epidemic diarrhea virus strain from Henan, China

文献类型： 外文期刊

作者： Li, Renfeng 1 ; Qiao, Songlin 2 ; Yang, Yanyan 2 ; Guo, Junqing 2 ; Xie, Sha 1 ; Zhou, Enmin 1 ; Zhang, Gaiping 3 ;

作者机构： 1.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

2.Henan Acad Agr Sci, Key Lab Anim Immunol, Henan Prov Key Lab Anim Immunol, Minist Agr, Zhengzhou 450002, Henan, Peoples R China

3.Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou 450002, Henan, Peoples R China

4.Henan Inst Sci & Technol, Coll Vet Med, Xinxiang 453003, Henan, Peoples R China

关键词： Porcine epidemic diarrhea virus;Recombination;Genome sequencing and analysis

期刊名称：VIRUS GENES （ 影响因子：2.332； 五年影响因子：2.0 ）

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收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) has caused devastating impact on pig-rearing industry in China and current vaccine is not effective against the circulating PEDV variants. In the present study, the full-length genome sequence from a PEDV isolate (CH/HNQX-3/14) was determined. The complete genome sequence analysis showed that the CH/HNQX-3/14 possessed unique deletion regions in the S and ORF3 genes. It was identified as a recombinant strain using phylogenetic analysis and recombination detection program. Further analyses of the full-length sequence suggest that CH/HNQX-3/14 is a natural recombinant between the attenuated vaccine strains (CV777 and DR13) and circulating wild-type strain (CH/ZMDZY/11). The recombination occurred not only in structural protein-coding region (S1 and N genes) but also in non-structural protein-coding region (replicases 1a and ORF3 genes). These results provided new evidence that PEDV strains circulating in China underwent recombination between vaccine and field strains, suggesting that recombination contributes to the genetic diversity of PEDV. Our findings provide valuable information on PEDV evolution and underscore the need for ongoing surveillance of this economically important swine disease.

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[1]Genomic analysis of a recombinant NADC30-like porcine reproductive and respiratory syndrome virus in china. Wang, Lin-jian,Guo, Zhenhua,Qiao, Songlin,Li, Rui,Xie, Sha,Chen, Xin-xin,Zhang, Gaiping,Wang, Lin-jian,Zhang, Gaiping,Wan, Bo,Zhang, Gaiping. 2018

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