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Molecular characterization of a novel reassortant H1N2 influenza virus containing genes from the 2009 pandemic human H1N1 virus in swine from eastern China

文献类型： 外文期刊

作者： Peng, Xiuming 1 ; Wu, Haibo 1 ; Xu, Lihua; Peng, Xiaorong 1 ; Cheng, Linfang 1 ; Jin, Changzhong 1 ; Xie, Tiansheng 2 ;

作者机构： 1.Zhejiang Univ, State Key Lab Diag & Treatment Infect Dis, Collaborat Innovat Ctr Diag & Treatment Infect Di, Affiliated Hosp 1,Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China

2.Zhejiang Univ, State Key Lab Diag & Treatmen

关键词： Swine influenza virus;H1N2;H1N1;Virus reassortment;Eastern China

期刊名称：VIRUS GENES （ 影响因子：2.332； 五年影响因子：2.0 ）

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收录情况： SCI

摘要： Pandemic outbreaks of H1N1 swine influenza virus have been reported since 2009. Reassortant H1N2 viruses that contain genes from the pandemic H1N1 virus have been isolated in Italy and the United States. However, there is limited information regarding the molecular characteristics of reassortant H1N2 swine influenza viruses in eastern China. Active influenza surveillance programs in Zhejiang Province identified a novel H1N2 influenza virus isolated from pigs displaying clinical signs of influenza virus infection. Whole-genome sequencing was performed and this strain was compared with other influenza viruses available in GenBank. Phylogenetic analysis suggested that the novel strain contained genes from the 2009 pandemic human H1N1 and swine H3N2 viruses. BALB/c mice were infected with the isolated virus to assess its virulence in mice. While the novel H1N2 isolate replicated well in mice, it was found to be less virulent. These results provide additional evidence that swine serve as intermediate hosts or 'mixing vessels' for novel influenza viruses. They also emphasize the importance of surveillance in the swine population for use as an early warning system for influenza outbreaks in swine and human populations.

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[1]Novel reassortant H10N7 avian influenza viruses isolated from chickens in Eastern China. Wu, Haibo,Wu, Xiaoxin,Peng, Xiaorong,Cheng, Linfang,Lu, Xiangyun,Jin, Changzhong,Xie, Tiansheng,Yao, Hangping,Wu, Nanping,Lu, Rufeng,Xu, Lihua.

[2]Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015. Wu, Haibo,Yang, Fan,Liu, Fumin,Peng, Xiuming,Wu, Nanping,Lu, Rufeng,Xu, Lihua. 2018

[3]Genetic characterization of novel reassortant H5N6-subtype influenza viruses isolated from cats in eastern China. Cao, Xueliang,Xu, Lihua,Cao, Xueliang,Yang, Fan,Wu, Haibo.

[4]Novel reassortant highly pathogenic H5N6 avian influenza viruses in poultry in China. Wu, Haibo,Peng, Xiaorong,Cheng, Linfang,Lu, Xiangyun,Jin, Changzhong,Xie, Tiansheng,Yao, Hangping,Wu, Nanping,Lu, Rufeng,Xu, Lihua.

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