Developmental exposure of zebrafish larvae to organophosphate flame retardants causes neurotoxicity
文献类型： 外文期刊
作者： Sun, Liwei 1 ; Xu, Wenbin 3 ; Peng, Tao 4 ; Chen, Haigang 5 ; Ren, Lin 3 ; Tan, Hana 4 ; Xiao, Dan 3 ; Qian, Haifeng 1 ; Fu, 1 ;
作者机构： 1.Zhejiang Univ Technol, Coll Environm, Hangzhou 310032, Zhejiang, Peoples R China
2.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310032, Zhejiang, Peoples R China
3.Zhejiang Univ Technol, Ocean Coll, Dept Food Sci & Technol, Hangzhou 310032, Zhejiang, Peoples R China
4.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310032, Zhejiang, Peoples R China
5.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, 231 Xingangxi Rd, Guangzhou 510300, Guangdong, Peoples R China
关键词： Nervous system;Acetylcholinesterase (AChE) activity;Gene transcriptional analysis;Locomotor behavior;Early life stage;Aquatic organism
期刊名称：NEUROTOXICOLOGY AND TERATOLOGY （ 影响因子：3.763； 五年影响因子：3.91 ）
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收录情况： SCI
摘要： With the gradual ban on brominated flame retardants (FRs), the application of organophosphate flame retardants (OPFRs) has increased remarkably. Considering the structural similarity between OPFRs and organophosphate pesticides, hypotheses that OPFRs may interfere with neurodevelopment as organophosphate pesticides are reasonable. In this study, the neurotoxicity of three OPFRs, including tri-n-butyl phosphate (TNBP), tris (2-butoxyethyl) phosphate (TBOEP) and tris (2-chloroethyl) phosphate (TCEP), was evaluated in zebrafish larvae and then compared with the neurotoxicity of organophosphate pesticide chlorpyrifos (CPF). The results showed that similar to CPF, exposure to OPFRs for 5 days resulted in significant changes in locomotor behavior, either in free swimming or in photomotor response. However, given the transcriptional changes that occur in nervous system genes in response to OPFRs and CPF, as well as the altered enzyme activity of AChE and its mRNA level, the underlying mechanisms for neurotoxicity among these organophosphate chemicals might be varied. In summary, the results confirm the potential neurodevelopmental toxicity of OPFRs and underscore the importance of identifying the mechanistic targets of the OPFRs with specific moieties. Furthermore, as the neurobehavioral responses are well conserved among vertebrates and the exposure of children to OPFRs is significant, a thorough assessment of the risk of OPFRs exposure during early development should be highly emphasized in future studies. (C) 2016 Elsevier Inc. All rights reserved.
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