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Pharmacokinetics and residue depletion of praziquantel in rice field eels Monopterus albus

文献类型： 外文期刊

作者： Xu, Ning 1 ; Dong, Jing 1 ; Yang, Yibin 1 ; Ai, Xiaohui 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fish Germplasm Qual Supervis & Testing, Minist Agr, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China

3.Hu Bei Freshwater Aquaculture Collaborat Innovat, Wuhan 430070, Peoples R China

4.Hu Bei Freshwater Aquaculture Collaborat Innovat, Wuhan 430070, Peoples R

关键词： Pharmacokinetics;Residue depletion;Praziquantel;Monopterus albus

期刊名称：DISEASES OF AQUATIC ORGANISMS （ 影响因子：1.802； 五年影响因子：2.148 ）

ISSN：

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收录情况： SCI

摘要： We investigated the pharmacokinetic characteristics of praziquantel (PZQ) in rice field eels Monopterus albus. Pharmacokinetic parameters were determined following a single intravenous administration (5 mg kg(-1) body weight [bw]) and a single oral administration (10 mg kg(-1) bw) at 22.0 +/- 0.7 degrees C. We also evaluated residue depletion in tissues following daily administration of PZQ (10 mg kg(-1) bw) that was given orally for 3 consecutive days at 22.0 +/- 0.7 degrees C. Following intravenous treatment, the plasma concentration-time curve was best described by a 3-compartment open model, with distribution half-life (t(1/2 alpha)), elimination half-life (t(1/2 beta)), and area under the concentration-time curve (AUC) of 0.54 h, 17.10 h, and 14505.12 h mu g l(-1), respectively. After oral administration, the plasma concentration-time curve was best described by a 1-compartment open model with first-order absorption, with absorption half-life (t(1/2Ka)), elimination half-life (t(1/2Ke)), peak concentration (C-max), time-to-peak concentration (T-max), and AUC estimated to be 2.28 h, 6.66 h, 361.29 mu g l(-1), 5.36 h, and 6065.46 h mu g l(-1), respectively. The oral bioavailability (F) was 20.9%. With respect to residue depletion of PZQ, the t(1/2 beta) values of muscle, skin, liver, and kidney were 20.2, 28.4, 14.9, and 54.1 h, respectively. Our results indicated rapid absorption, rapid elimination, and low bioavailability of PZQ in rice field eels at the tested dosing conditions.

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