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Targeted solid phase fermentation of the soil dwelling fungus Gymnascella dankaliensis yields new brominated tyrosine-derived alkaloids

文献类型： 外文期刊

作者： Wang, Hao 1 ; Dai, Haofu 2 ; Heering, Christian 3 ; Janiak, Christoph 3 ; Lin, Wenhan 4 ; Orfali, Raha S. 5 ; Mueller, 1 ;

作者机构： 1.Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

3.Heinrich Heine Univ Dusseldorf, Inst Inorgan & Struct Chem, Univ Str 1, D-40225 Dusseldorf, Germany

4.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

5.King Saud Univ, Fac Pharm, Dept Pharmacognosy, Riyadh, Saudi Arabia

6.Johannes Gutenberg Univ Mainz, Univ Med, Inst Physiol Chem, Duesbergweg 6, D-55128 Mainz, Germany

期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）

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收录情况： SCI

摘要： Seven new brominated tyrosine-derived alkaloids, gymnastatins T-Y (1-6) and dankastatin D (7), together with three known likewise brominated analogues gymnastatins I-K (8-10) were isolated from the soil fungus Gymnascella dankaliensis through fermentation on solid rice medium following addition of NaBr. None of these compounds were detected when the fungus was cultured on rice that either lacked NaBr or that contained NaCl instead, indicating a remarkable plasticity of the fungal secondary metabolism. All structures were elucidated on the basis of one and two dimensional NMR spectroscopic analyses and MS data. The absolute configuration of the new gymnastatin T (1) was determined by X-ray crystallographic data. All isolated alkaloids showed potent to moderate cytotoxicity against the L5178Y mouse lymphoma cell line with IC50 values ranging from 0.078 to 14.1 mu M.

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