CYP1A1 mediates the suppression of major inflammatory cytokines in pulmonary alveolar macrophage (PAM) cell lines caused by Mycoplasma hyponeumoniae
文献类型: 外文期刊
作者: Fang, Xiaomin 1 ; Zhao, Weimin 1 ; Xu, Jie 1 ; Tu, Feng 1 ; Wang, Xuemin 1 ; Li, Bixia 1 ; Fu, Yanfeng 1 ; Ren, Shouwen 1 ;
作者机构: 1.Jiangsu Acad Agr Sci, Inst Anim Sci, 50 Zhongling St, Nanjing 210014, Jiangsu, Peoples R China
关键词: Pig;CYP1A1;Mycoplasma hyopneumoniae;Inflammatory response
期刊名称:DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY ( 影响因子:3.636; 五年影响因子:3.654 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Mycoplasmal pneumonia is a lung infection disease caused by Mycoplasma hyopneumoniae in swine. We previously reported that Cytochrome P450 1A1 (CYP1A1) expression was significantly downregulated in pigs infected with M. hyopneumoniae compared to the healthy controls. In this study, pulmonary alveolar macrophage (PAM) cell lines with CYP1A1 overexpression or siRNA-mediated CYP1A1 silencing were used to explore the biological function and regulatory mechanism of CYP1A1 gene expression changed on the inflammatory response of pigs infected with M. hyopneumoniae. The results showed that the cells overexpressing CYP1A1 infected with M. hyopneumoniae led to a rapid increase in PPAR-gamma expression, which resulted in decreasing the levels of several inflammatory cytokines including IL-1 beta, IL-6, IL-8 and TNF-alpha. On the contrary, this effect was just opposite in CYP1A1-RNAi cells infected with M. hyopneumoniae. We suggest that CYP1A1 suppress the inflammatory response caused by M. hyopneumoniae infection, via PPAR-gamma signaling pathway in pigs. (C) 2016 Elsevier Ltd. All rights reserved.
- 相关文献
作者其他论文 更多>>
-
Berberine alleviates inflammation in polycystic ovary syndrome by inhibiting hyaluronan synthase 2 expression
作者:He, Shaojing;Zhang, Qianjie;Li, Wei;Yang, Jing;Li, Saijiao;He, Shaojing;Li, Hui;Zhang, Qianjie;Zhao, Weimin;Dai, Chaohui;Li, Bixia;Cheng, Jinhua;Li, Hui;Zhao, Weimin;Dai, Chaohui;Li, Bixia;Cheng, Jinhua;Wu, Shuang;Zhou, Zhongming
关键词:HAS2; Inflammation; Granulosa cell; Berberine; PCOS
-
Aqueous M. oleifera leaf extract alleviates DSS-induced colitis in mice through suppression of inflammation
作者:Zhang, Shuai;Cao, Yanan;Huang, Yanjie;Zhang, Shuoshuo;Wang, Guangzheng;Bao, Wenbin;Fang, Xiaomin;Bao, Wenbin
关键词:M. oleifera; Inflammatory bowel disease; Intestinal organoids; TNF-& alpha; Dextran sulfate sodium; Network pharmacology
-
Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis
作者:Li, Teng;Zhang, Shujuan;Li, Xuebing;Yuan, Jingya;Zhang, Wenhua;Zhang, Qun;Yao, Shuaibing;Wang, Xuemin;Yao, Shuaibing;Wang, Xuemin;Jia, Qianru
关键词:
-
Porcine Deltacoronavirus Infection Disrupts the Intestinal Mucosal Barrier and Inhibits Intestinal Stem Cell Differentiation to Goblet Cells via the Notch Signaling Pathway
作者:Zhang, Shuai;Zhang, Shuoshuo;Huang, Yanjie;Wang, Guangzheng;Cao, Yanan;Bao, Wenbin;Hou, Yuchen;Chen, Zhenhai;Cai, Jiajia;Fang, Xiaomin
关键词:Notch signaling pathway; PDCoV; goblet cells; intestinal organoids; intestinal stem cells
-
Lipopolysaccharide accelerates tryptophan degradation in the ovary and the derivative kynurenine disturbs hormone biosynthesis and reproductive performance
作者:Shen, Jie;Cheng, Juanru;Zhao, Lei;Shi, Deshun;Deng, Yanfei;Shen, Jie;Zhao, Weimin;Cheng, Jinhua;Zhao, Lei;Dai, Chaohui;Fu, Yanfeng;Li, Bixia;Chen, Zhe;Li, Hui
关键词:LPS; Tryptophan; Kynurenine; Granulosa cell; Reproduction
-
Bioactive functions of chlorogenic acid and its research progress in pig industry
作者:Dai, Chaohui;Li, Hui;Zhao, Weimin;Fu, Yanfeng;Cheng, Jinhua;Dai, Chaohui;Li, Hui;Zhao, Weimin;Fu, Yanfeng;Cheng, Jinhua;Dai, Chaohui;Li, Hui;Zhao, Weimin;Fu, Yanfeng;Cheng, Jinhua
关键词:chlorogenic acid; feed additive; performance improvement; pig
-
TGF-beta 1 suppresses de novo cholesterol biosynthesis in granulosa-lutein cells by down-regulating DHCR24 expression via the GSK-3 beta/EZH2/H3K27me3 signaling pathway
作者:Li, Hui;Zhao, Fang;Zhao, Weimin;Chen, Fang;Fu, Yanfeng;Li, Bixia;Cheng, Jinhua;Shen, Jie;Deng, Yanfei;Ma, Shinan
关键词:TGF-01; DHCR24; De novo cholesterol biosynthesis