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Nematicidal Stemona Alkaloids from Stemona parviflora

文献类型: 外文期刊

作者: Huang, Sheng-Zhuo 1 ; Kong, Fan-Dong 1 ; Ma, Qing-Yun 1 ; Guo, Zhi-Kai 1 ; Zhou, Li-Man 1 ; Wang, Qi 1 ; Dai, Hao-Fu 1 ;

作者机构: 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

2.Chinese A

期刊名称:JOURNAL OF NATURAL PRODUCTS ( 影响因子:4.05; 五年影响因子:4.603 )

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收录情况: SCI

摘要: Eight new alkaloids, 3 beta-n-butylstemonamine (1), 8-oxo-3 beta-n-butylstemonamine (2), 3-n-butylneostemonine (3), 10-epi-3-n-butylneostemonine (4), 8-oxo-oxymaistemonine (5) protostemonine N-4-oxide (6), (19S)-hydroxy-21-methoxystemofoline (7), and parvistemonine A (8), were isolated from the roots of Stemona parviflora, together with 17 known alkaloids. The structures of the new alkaloids were elucidated based on a comprehensive spectroscopic data analysis. The absolute configurations of 1-4 were determined by the ECD exciton chirality method and quantum ECD calculations. Protostemonine (10) and stemofoline (12) showed strong nematicidal activity against Panagrellus redivevus, with IC50 values of 0.10 and 0.46 mu M, respectively.

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