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Phenolic bisabolanes from the sponge-derived fungus Aspergillus sp.

文献类型： 外文期刊

作者： Liu, Shuai 1 ; Dai, Haofu 2 ; Konuklugil, Belma 3 ; Orfali, Raha S. 4 ; Lin, Wenhan 5 ; Kalscheuer, Rainer 1 ; Liu, Zh 1 ;

作者机构： 1.Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

3.Ankara Univ, Dept Pharmacognosy, Fac Pharm, TR-06110 Ankara, Turkey

4.King Saud Univ, Dept Pharmacognosy, Fac Pharm, Riyadh, Saudi Arabia

5.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

关键词： Sponge-derived fungus;Aspergillus sp.;Phenolic bisabolanes;Antibacterial;Co-cultivation

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

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收录情况： SCI

摘要： Two new phenolic bisabolane sesquiterpenes, asperchondols A (1) and B (2), together with seven known analogues (3-9) and four known diphenyl ethers (10-13) were obtained from Aspergillus sp., that had been isolated from the marine sponge Chondrilla nucula. Their structures were elucidated through NMR and MS analysis, and by comparison with literature data. All isolated compounds were evaluated for their antibacterial activity against eight human pathogenic bacteria. Co-cultivation experiment of Aspergillus sp. with Bacillus subtilis was also conducted. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.

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