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Unusual Cytotoxic Steroidal Saponins from the Gorgonian Astrogorgia dumbea

文献类型： 外文期刊

作者： Lu, Ya-Nan 1 ; Cui, Ping 2 ; Tian, Xiao-Qing 1 ; Lou, Li-Guang 3 ; Fan, Cheng-Qi 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Key Lab East China Sea & Ocean Fishery Resources, Minist Agr, East China Sea Fisheries Res Inst, Shanghai, Peoples R China

2.Changchun Univ Chinese Med, Changchun, Peoples R China

3.Chinese Acad Sci, Shanghai Inst Mat Medica, Shanghai, Peoples R China

关键词： Astrogorgia dumbea;Plexauridae;steroidal saponin;astrogorgiosides A-C;cytotoxic activity

期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）

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收录情况： SCI

摘要： Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near Dongshan Island in East China Sea. Structures of these compounds were elucidated by in-depth spectral and chemical methods, including 2D-NMR, HR-ESI-ESI-MS spectra, and acidic hydrolysis. For the first time, acetamido-glucose moiety is being reported from a gorgonian. The B-ring aromatized steroid aglycone of compound 3 is also rare in marine natural products. Compounds 1-3 exhibited moderate cytotoxic activity with IC50 values of 26.8-45.6 mu M against human tumor cells Bel-7402 and K562.

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