Hepatoprotection of enzymatic-extractable mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis
文献类型： 外文期刊
作者： Xu, Nuo 1 ; Gao, Zheng 2 ; Zhang, Jianjun 2 ; Jing, Huijuan 2 ; Li, Shangshang 2 ; Ren, Zhenzhen 2 ; Wang, Shouxian 1 ; J 1 ;
作者机构： 1.Beijing Acad Agr & Forestry Sci, Beijing Engn Res Ctr Edible Mushroom, Inst Plant & Environm Protect, Key Lab Urban Agr North,Minist Agr, Beijing, Peoples R China
2.Shandong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China
关键词： Hepatoprotective effects;Enzymatic-extractable;Mycelia zinc polysaccharides;Pleurotus eryngii var. tuoliensis
期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）
ISSN：
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收录情况： SCI
摘要： The purpose of this work was designed to investigate the hepatoprotective and antioxidant effects of enzymatic-extractable mycelia zinc polysaccharides (En-MZPS) from Pleurotus eryngii var. tuoliensis on the hyperlipidemic mice induced by high-fat-high-cholesterol emulsion (HFHCM). The results showed that the supplementation of En-MZPS had potential anti-hyperlipidemia effects on reducing hepatic lipid levels by monitoring the serum enzyme activities (ALP, ALT and AST) and serum lipid levels (TC, TG, HDL-C, LDL-C and VLDL-C), enhancing the antioxidant enzymes (SOD, GSH-Px, CAT and T-AOC), and decreasing the lipid peroxidation (MDA and LPO). Furthermore, the in vitro scavenging results indicated that the inhibition effects of En-MZPS on hydroxyl radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals reached 59.98 6.29% and 37.01 +/- 2.15%, respectively. These conclusions demonstrated that the En-MZPS might be suitable for functional foods and natural drugs in preventing the HFHCM-induced hyperlipidemia and non-alcoholic fatty liver. (C) 2016 Elsevier Ltd. All rights reserved.
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