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Inducing new secondary metabolites through co-cultivation of the fungus Pestalotiopsis sp with the bacterium Bacillus subtilis

文献类型： 外文期刊

作者： Liu, Shuai 1 ; Dai, Haofu 2 ; Heering, Christian 3 ; Janiak, Christoph 3 ; Lin, Wenhan 4 ; Liu, Zhen 1 ; Proksch, Pete 1 ;

作者机构： 1.Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

3.Heinrich Heine Univ Dusseldorf, Inst Inorgan & Struct Chem, Univ Str 1, D-40225 Dusseldorf, Germany

4.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

关键词： Pestalotiopsis sp.;Bacillus subtilis;Co-cultivation

期刊名称：TETRAHEDRON LETTERS （ 影响因子：2.415； 五年影响因子：2.036 ）

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收录情况： SCI

摘要： Two new lactones, pestalotiolactones A (1) and B (2), together with three known compounds (3-5) were isolated from the axenic culture of the endophytic fungus Pestalotiopsis sp., obtained from fruits of Drepanocarpus lunatus (Fabaceae). Co-culture of this fungus with Bacillus subtilis afforded two new sesquiterpenoids pestabacillins A (6) and B (7) as well as eight known compounds (8-15). Their structures were elucidated by extensive analysis of the NMR and MS data as well as by comparison with literature data. All isolated compounds were evaluated for their cytotoxic and antimicrobial activities but proved to be inactive. (C) 2016 Elsevier Ltd. All rights reserved.

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