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Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus

文献类型： 外文期刊

作者： Kong, Fan-Dong 1 ; Ma, Qing-Yun 1 ; Huang, Sheng-Zhuo 1 ; Wang, Pei 1 ; Wang, Jun-Feng; Zhou, Li-Man 1 ; Yuan, Jing 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

2.Chinese A

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

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收录情况： SCI

摘要： Six new meroterpenoids, chrodrimanins K-N (1-4), including two uncommon chlorinated one (1 and 2), and verruculides B2 (5) and B3 (6), as well as seven known ones (7-13), were isolated from the fermentation broth of Penitillinm sp. SCS-KFD09, isolated from a marine worm, Sipunculus nuchis, from Haikou Bay, China., The, structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data, X-ray diffraction analysis, and ECD spectra analysis along with quantum ECD calculations. In addition, the X-ray crystal structures and, absolute configurations :of two previously reported tneroterpenoids, chrodrimanins F (9) and A (11), are described for the first time. Compounds 1, 4, and 7 displayed anti-H1N1 activity with IC50 values of-74,, 58, and 34 mu M, respectively, while compound 5 showed, weak inhibitory activity against Staphylococcus atireas with an MIC of 32 mu g/mL.

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